Metal accumulation and toxicity: the critical accumulated concentration of metabolically available zinc in an oyster model

Aquatic Toxicology
Philip S RainbowWen-Xiong Wang

Abstract

Invertebrates typically carry out detoxification of accumulated metals. There is, therefore, no threshold total body concentration of accumulated metal initiating toxicity, the onset of toxic effects rather being related to a critical concentration of metabolically available (MA) accumulated metal. The challenge remains as to whether any particular combination of subcellular fractions of accumulated metal can be identified to represent this theoretical MA component. One candidate combined fraction is the so-termed metal sensitive fraction (MSF), consisting of metal bound to organelles and non-detoxificatory soluble proteins. In this study, we used laboratory zinc accumulation and toxicity data for four populations of the oyster Crassostrea hongkongensis with different histories of zinc exposure in the field to address the challenge. We conclude that in a 'control' population of the oyster, the MSF does approximate to the theoretical metabolically available zinc concentration. In populations with a history of field exposure to raised zinc bioavailabilities, however, the MSF would include more zinc detoxified in the lysosome component of organelle-bound metal, and the MSF in such populations would deviate more from the theoretica...Continue Reading

References

Mar 8, 2008·Environmental Science & Technology·Mengjiao Wang, Wen-Xiong Wang
Aug 10, 2010·Environmental Pollution·M Carmen Casado-MartinezPhilip S Rainbow
May 12, 2011·Environmental Toxicology and Chemistry·Wen-Xiong WangCaihuan Ke
Aug 9, 2012·Environmental Science & Technology·Qiao-Guo Tan, Wen-Xiong Wang
Mar 5, 2013·Aquatic Toxicology·Fengjie LiuWen-Xiong Wang

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Citations

Sep 18, 2015·Environmental Toxicology and Chemistry·Guillaume BucherSandrine Frelon
May 8, 2020·Environmental Science and Pollution Research International·Lifei WangXiaoping Jia
Sep 23, 2020·Environmental Science and Pollution Research International·Sabrina Loise de Moraes CaladoMárcia Santos de Menezes
Jun 12, 2017·Environmental Science and Pollution Research International·Jamshed AliNaeem Ullah
Jul 30, 2020·Food Science & Nutrition·Shan HeYang Yuan
Aug 14, 2020·Environmental Science & Technology·Luqing ZhangWen-Xiong Wang

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