Metal-based biologically active agents: Synthesis, characterization, antibacterial and antileukemia activity evaluation of Cu(II), V(IV) and Ni(II) complexes with antipyrine-derived compounds

European Journal of Medicinal Chemistry
Tudor RosuAurelian Gulea

Abstract

The paper presents the synthesis of complex combinations of Cu(II), V(IV) and Ni(II) with Schiff bases obtained through the condensation of 4-amino-1,5-dimethyl-2-phenyl-1H-3-pyrazol-3(2H)-one (antipyrine) with 2-hydroxybenzaldehyde, 4-hydroxy-5-methoxyisophthalaldehyde and 4,5-dihydroxyisophalaldehyde respectively. The characterization of newly formed complexes was done by (1)H NMR, (13)C NMR, UV-VIS, IR, EPR spectroscopies and molar electric conductibility studies. The effect of these complexes on proliferation of human leukemia cells (HL-60) and their antibacterial activity against Staphylococcus aureus var. Oxford 6538, Escherichia coli ATCC 10536 and Candida albicans ATCC 10231strains were studied and compared with those of free ligands.

References

Jun 1, 1991·American Journal of Diseases of Children·B ZuckermanH Cabral
Jul 1, 1970·Journal of Medicinal Chemistry·E M Hodnett, W J Dunn
Nov 17, 2007·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tudor RosuRaluca Cernat

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Citations

Jul 6, 2014·Journal of Photochemistry and Photobiology. B, Biology·Muthusamy SelvaganapathyNatarajan Raman
May 29, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sanaa Moustafa EmamNagla Nassar
Apr 8, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elena PahonțuTudor Roșu
May 8, 2014·Science Progress·Ruth J McQuitty
Oct 1, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Xiangwen LiaoMingpei Liu
Apr 7, 2011·Archiv der Pharmazie·Annegret HilleBrigitte Kircher

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