Metal based nanoparticles as cancer antigen delivery vehicles for macrophage based antitumor vaccine

Vaccine
Sourav ChattopadhyaySomenath Roy

Abstract

In the present study, we would like to evaluate the efficacy of modified metal oxide nanoparticles (NPs) as cancer antigen delivery vehicles for macrophage (MФs) based antitumor vaccine. The cobalt oxide nanoparticles (CoO NPs) were promising tools for delivery of antigens to antigen presenting cells and have induced an antitumor immune response. Synthesized CoO NPs were modified by N-phosphonomethyliminodiacetic acid (PMIDA), facilitated the conjugation of lysate antigen, i.e. cancer antigen derived from lysis of cancer cells. The cancer cell lysate antigen conjugated PMIDA-CoO NPs (Ag-PMIDA-CoO NPs) successfully activated macrophage (MФ) evident by the increasing the serum IFN-γ and TNF-α level. Immunization of mice with the Ag-PMIDA-CoO NPs constructed an efficient immunological adjuvant induced anticancer IgG responses, and increased the antibody dependent cellular cytotoxicity (ADCC) response than only lysate antigen treated group to combat the cancer cell. The nanocomplexes enhanced the anticancer CD4(+)T cell response in mice. The result showed that Ag-PMIDA-CoO NPs can stimulate the immune responses over only lysate antigens, which are the most important findings in this study. These NP-mediated Ag deliveries may signif...Continue Reading

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Citations

Oct 26, 2018·Expert Opinion on Drug Metabolism & Toxicology·Anne RodallecJoseph Ciccolini
Jun 25, 2020·Nanoscale·Nurul 'Ain AzmanJames Chen Yong Kah
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Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

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