Metal cation-fluoroquinolone complexes do not permeate through the intestinal absorption barrier

Journal of Pharmaceutical and Biomedical Analysis
Zakelj SimonKristl Albin

Abstract

A case of a clinically significant interaction between a fluoroquinolone antimicrobial agent and metal cations was first reported in 1985. The hypothesized mechanism--decreased fluoroquinolone intestinal permeability due to complex formation between metal cations and ciprofloxacin--was based on a 1978 work with nalidixic acid. While clinical research and numerous in vitro physico-chemical and chelation chemistry studies of fluoroquinolone-metal cation combinations simply accepted this explanation, the few in vitro studies, which were aimed to investigate the nature of the interaction mechanism, provided conflicting results. This was most likely due to the sensitivity of the interaction to in vivo conditions, which were not reproduced in vitro. All the above-mentioned studies including our earlier work in vitro were performed with diluted solutions of fluoroquinolones and metal cations. Now we provide results obtained on rat intestine in side-by-side diffusion chambers with saturated solutions of fluoroquinolones and metal cations in the donor compartment as it is most likely in the human small intestine in vivo. The fluoroquinolone permeability decreased under these conditions in the presence of metal cations and the obtained r...Continue Reading

References

May 1, 1978·Chemical & Pharmaceutical Bulletin·M NakanoT Arita
Apr 1, 1992·Antimicrobial Agents and Chemotherapy·R W FrostJ T Lettieri
Mar 1, 1991·British Journal of Clinical Pharmacology·M KaraN R Campbell
Mar 1, 1990·Antimicrobial Agents and Chemotherapy·D E NixA Norman
Apr 1, 1986·European Journal of Clinical Microbiology·K BornerD Reinitz
Jun 1, 1985·European Journal of Clinical Microbiology·G HöffkenH Lode
May 1, 1985·Journal of Pharmaceutical Sciences·J B DressmanD Fleisher
May 1, 1995·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·B M Lomaestro, G R Bailie
Jul 1, 1994·The Journal of Antimicrobial Chemotherapy·A Sánchez NavarroA Dominguez-Gil Hurlé
Oct 1, 1993·Antimicrobial Agents and Chemotherapy·M TanakaH Hakusui
Apr 25, 1996·The New England Journal of Medicine·I Skoog
Dec 1, 1996·Kidney International·T H IttelH G Sieberth
Mar 11, 1998·Acta Physiologica Scandinavica·J D SöderholmG Olaison
Jan 27, 1999·Journal of Pharmaceutical and Biomedical Analysis·M Córdoba-DíazD Córdoba-Díaz
Apr 27, 2001·Pharmacology & Toxicology·R A Yokel, P J McNamara
Mar 17, 2004·International Journal of Pharmaceutics·Simon ZakeljAlbin Kristl
Mar 15, 2006·International Journal of Pharmaceutics·Simon ZakeljAlbin Kristl
Dec 19, 2006·International Journal of Pharmaceutics·Anwar R ShaikhMange Ram Yadav

❮ Previous
Next ❯

Citations

Jun 22, 2013·Journal of the American Veterinary Medical Association·Olivia A PetritzMark G Papich
Dec 7, 2013·AAPS PharmSciTech·Aleksandra StojkovicOwen I Corrigan
Sep 14, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valentina Uivarosi
Nov 11, 2015·Drug Development and Industrial Pharmacy·Julia Anita GrießingerAndreas Bernkop-Schnürch
Jul 27, 2011·Journal of Pharmaceutical Sciences·Jelena ParojčićOwen I Corrigan
Dec 8, 2015·Molecular Pharmaceutics·Frederic TewesAnne Marie Healy
May 9, 2014·Drug Metabolism and Pharmacokinetics·Ayuko ImaokaHisakazu Ohtani
Jan 5, 2019·Biological & Pharmaceutical Bulletin·Yuji SaitoMasayuki Nadai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.