Abstract
Various food constituents have been proposed as disease-modifying agents for Alzheimer's disease (AD), due to epidemiological evidence of their beneficial effects, and for their ability to ameliorate factors linked to AD pathogenesis, namely by: chelating iron, copper and zinc; scavenging reactive oxygen species; and suppressing the fibrillation of amyloid-beta peptide (Aβ). In this study, nine different food constituents (l-ascorbic acid, caffeic acid, caffeine, curcumin, (-)-epigallocatechin gallate (EGCG), gallic acid, propyl gallate, resveratrol, and α-tocopherol) were investigated for their effects on the above factors, using metal chelation assays, antioxidant assays, and assays of Aβ42 fibrillation. An assay method was developed using 5-Br-PAPS to examine the complexation of Zn(II) and Cu(II). EGCG, gallic acid, and curcumin were identified as a multifunctional compounds, however their poor brain uptake might limit their therapeutic effects. The antioxidants l-ascorbic acid and α-tocopherol, with better brain uptake, deserve further investigation for specifically addressing oxidative stress within the AD brain.
References
Aug 1, 1988·Journal of Neurochemistry·G T VatasseryM G Traber
Dec 18, 1972·Annals of the New York Academy of Sciences·A L Tappel
Apr 1, 1971·Analytical Biochemistry·P Carter
Mar 26, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·T MakinoK Kina
Mar 22, 1996·The Journal of Biological Chemistry·T TomiyamaN Endo
May 20, 1998·Lipids·H Shi, E Niki
Mar 3, 2004·Journal of Neuroscience Research·Kenjiro OnoMasahito Yamada
Apr 16, 2004·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Marganta Bernabé-PinedaAlberto Rojas-Hernández
Jun 25, 2005·Current Alzheimer Research·John M RingmanJeffrey L Cummings
Oct 21, 2005·Organic Letters·Malgorzata Musialik, Grzegorz Litwinienko
Jan 20, 2006·The European Journal of Neuroscience·Stéphane BastianettoRémi Quirion
Jul 28, 2006·American Journal of Epidemiology·Tze-Pin NgEe-Heok Kua
Mar 21, 2007·Accounts of Chemical Research·Grzegorz Litwinienko, K U Ingold
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Jun 25, 2008·The British Journal of Nutrition·Jeremy P E Spencer
May 31, 2008·Nature Structural & Molecular Biology·Dagmar E EhrnhoeferErich E Wanker
Jun 17, 2008·Inorganic Chemistry·Nathan R PerronJulia L Brumaghim
Feb 13, 2010·The Journal of Biological Chemistry·Saviana Di GiovanniHilal A Lashuel
Apr 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jan BieschkeErich E Wanker
Oct 21, 2011·Genes & Nutrition·Sebastian Schaffer, Barry Halliwell
Jan 18, 2012·Journal of Molecular Biology·Marcus Fändrich
Sep 18, 2012·Neurochemistry International·Mark A GreenoughAshley I Bush
Feb 20, 2013·The Journal of Physical Chemistry. a·Florent Di MeoPatrick Trouillas
Apr 25, 2013·Journal of the American Chemical Society·Fernando L PalhanoJeffery W Kelly
Jun 25, 2013·The Journal of Biological Chemistry·Mizuho SatoKazuhiro Irie
Jul 31, 2013·Neuropharmacology·R AnandAbbas Ali Mahdi
Dec 10, 2013·Journal of the American Chemical Society·Paolo ArosioSara Linse
Apr 26, 2014·Nutrients·Fiona E HarrisonMaria Cristina Polidori
Aug 31, 2014·Bioorganic & Medicinal Chemistry Letters·Hemalatha RajaramBenjamin P Ross
Citations
Jun 27, 2017·ACS Chemical Neuroscience·Srinivas KanthamBenjamin P Ross
Feb 6, 2017·Frontiers in Neuroscience·Mattia ToniEnzo Spisni
Dec 31, 2016·Redox Biology·Ting-Ting AnCheng-Ming Zeng
Jun 28, 2017·Nutrients·Joanna KocotJacek Kurzepa
Jun 28, 2017·Nutrients·Fiammetta MonacelliAlessio Nencioni
Aug 11, 2016·Food & Function·Min WuJianzhong Han
Dec 5, 2017·Journal of Alzheimer's Disease : JAD·Paulami ChatterjeeNitin Rathi
Sep 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bharath Kumar VelmuruganChing-Feng Weng
Aug 12, 2017·Critical Reviews in Food Science and Nutrition·Elif Celik, Nevin Sanlier
May 30, 2017·Frontiers in Pharmacology·Chen DilingXie Yizhen
May 24, 2020·International Journal of Molecular Sciences·Hatasu KobayashiShinji Oikawa
Jul 17, 2020·International Journal of Molecular Sciences·Estelle PalierseThibaud Coradin
Mar 12, 2017·Molecular Neurobiology·Fernanda Rafaela JardimMarcos Roberto de Oliveira
May 26, 2017·Biomedicines·Rafael Vincent ManaloPaul Mark Medina
Feb 24, 2018·Scientific Reports·Zhiqiang JiangYan Sun
Oct 8, 2018·Molecular Diversity·Yash Pal SinghGyan Modi
Dec 2, 2018·Frontiers in Pharmacology·Abha SharmaS J S Flora
Aug 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yilong TengPing Zhou
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Johant Lakey-BeitiaK S Rao
Jun 11, 2020·Arquivos de neuro-psiquiatria·Júlia Canto E SousaGabriela Jesus Prado Magalhães
Sep 4, 2020·Scientific Reports·Andrius SakalauskasVytautas Smirnovas
Apr 30, 2017·Chemical Science·S PellegrinoS Ongeri
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Huanhuan XuJun Sheng
Aug 23, 2018·International Journal of Oncology·Wangping LiFaguang Jin
May 16, 2019·Pancreas·Pimpisid KoonyosyingSomdet Srichairatanakool
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lijuan YangShifa Wang
Jun 22, 2018·Neural Regeneration Research·Aline FreyssinAgnès Rioux Bilan
Nov 13, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Reham Z HamzaNahla S El-Shenawy
Nov 27, 2020·Food & Function·Dan WuSongyi Lin
Dec 9, 2020·Physical Chemistry Chemical Physics : PCCP·Anupamjeet KaurBhupesh Goyal
Jan 16, 2021·Chemistry & Biodiversity·Asha HiremathadRangappa S Keri
Dec 23, 2020·International Journal of Biological Macromolecules·Fufeng LiuFuping Lu
Aug 11, 2020·European Journal of Pharmacology·Md Sahab UddinLotfi Aleya
Mar 7, 2021·Antioxidants·Andrea BacciSimona Rapposelli
Jan 26, 2018·Bioorganic Chemistry·Aida IrajiRamin Miri
Jun 3, 2021·Cells·Icksoo Lee
Aug 8, 2021·Nanomaterials·Marta Fiedot-TobołaJoanna Cybińska
Aug 22, 2017·ACS Chemical Neuroscience·Girdhar Singh DeoraBenjamin P Ross
Jan 13, 2018·Molecular Pharmaceutics·Roberta GiampietroNicola Antonio Colabufo
May 22, 2020·ACS Chemical Neuroscience·Alejandro Sánchez-MelgarMairena Martín
Oct 24, 2020·Journal of Agricultural and Food Chemistry·Maria Elisa Caetano-SilvaMaria Teresa Bertoldo Pacheco
May 27, 2020·Journal of Agricultural and Food Chemistry·Dan WuSongyi Lin
Aug 17, 2021·ChemMedChem·Hang ZhaoZhiqian Tong