Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease.

Journal of Nanoneuroscience
Gang LiuMark A Smith

Abstract

Alzheimer's disease (AD) is a devastating neuro-degenerative disorder characterized by the progressive and irreversible loss of memory followed by complete dementia. Despite the disease's high prevalence and great economic and social burden, an explicative etiology or viable cure is not available. Great effort has been made to better understand the disease's pathogenesis, and to develop more effective therapeutic agents. However, success is greatly hampered by the presence of the blood-brain barrier that limits a large number of potential therapeutics from entering the brain. Nanoparticle-mediated drug delivery is one of the few valuable tools for overcoming this impediment and its application as a potential AD treatment shows promise. In this review, the current studies on nanoparticle delivery of chelation agents as possible therapeutics for AD are discussed because several metals are found excessive in the AD brain and may play a role in the disease development. Specifically, a novel approach involving transport of iron chelation agents into and out of the brain by nanoparticles is highlighted. This approach may provide a safer and more effective means of simultaneously reducing several toxic metals in the AD brain. It may a...Continue Reading

Citations

Dec 25, 2013·Genes & Nutrition·Johnathan R Nuttall, Patricia I Oteiza
Mar 12, 2011·Expert Opinion on Drug Delivery·Antonio Di StefanoPiera Sozio
Oct 26, 2011·Journal of Drug Targeting·Mohammad FazilJaved Ali
Apr 1, 2015·Future Medicinal Chemistry·M Amélia Santos, Sílvia Chaves
May 18, 2021·Frontiers in Bioengineering and Biotechnology·Nazeer Hussain KhanXin-Ying Ji
Jun 18, 2021·Biomaterials Research·Seong-Jong KimSei Kwang Hahn

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