PMID: 9542061May 9, 1998Paper

Metal complexes of bovine lactoferrin inhibit in vitro replication of herpes simplex virus type 1 and 2

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Magda MarchettiN Orsi

Abstract

The inhibitory effect of bovine lactoferrin (BLf) saturated with ferric, manganese or zinc ions, on the infection of Vero cells by human herpes simplex virus type 1 (HSV1) and 2 (HSV2) was investigated. Viral infectivity determined by intracellular antigen synthesis and plaque formation was efficiently inhibited by metal saturated lactoferrins in a dose-dependent manner. Effective BLf concentrations which reduced the infection by 50% ranged from 5.2 to 31 micrograms ml-1 and were far below the cytotoxicity threshold. Fe3+BLf and Mn2+BLf exhibited selectivity indexes higher than Zn2+BLf and apoBLf for both viruses and the effect was mainly directed towards the early steps of infection. The slight viral inhibition shown by the citrate complexes of the different metals could indicate that the antiviral effect was not significantly influenced by Fe3+, Mn2+ or Zn2+ ions delivered by BLf into the cells.

Citations

Oct 21, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Grzegorz MajkaMagdalena Strus
May 29, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jagat R KanwarRupinder K Kanwar
Aug 31, 2001·Antiviral Chemistry & Chemotherapy·G LampiR Pompei
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Francesco GiansantiLucilla Seganti
Jul 25, 2003·Antimicrobial Agents and Chemotherapy·Agostina PietrantoniFabiana Superti
Sep 3, 2003·Veterinary Ophthalmology·Stephanie L BeaumontHeather E Clarke
Sep 24, 2008·Medical Microbiology and Immunology·Songtao LiNing Liu
Mar 20, 2013·Journal of Medical Virology·Paula E FlorianNorica Branza-Nichita
Oct 1, 2016·Pharmaceuticals·Francesco GiansantiGiovanni Antonini
Sep 17, 2020·International Journal of Molecular Sciences·Aldo VaggeGiuseppe Giannaccare
Jul 16, 2020·International Journal of Molecular Sciences·Elena CampioneLuca Bianchi
Nov 8, 2001·The Journal of Pharmacy and Pharmacology·E D Weinberg
Jun 3, 2009·Expert Review of Anti-infective Therapy·Mohan Venkatesh, Steven Abrams
Apr 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Romina MancinelliPiera Valenti
Feb 26, 2003·Journal of Medical Virology·Assunta Maria Di BiaseFabiana Superti
May 2, 2003·Expert Opinion on Investigational Drugs·Eugene D Weinberg
Feb 16, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Agostina PietrantoniFabiana Superti
Jul 25, 2013·Expert Review of Anti-infective Therapy·Krithika LingappanMohan Pammi
Aug 4, 2019·Viruses·Aslaa AhmedAarthi Narayanan
Mar 7, 2019·Frontiers in Genetics·Amanat AliRanjit Vijayan
Dec 22, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·L H Vorland
Sep 29, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Anthony L NewsomeMichael W Thompson
Dec 4, 2009·Virologica Sinica·Christopher D O'Donnell, Deepak Shukla
Nov 10, 2020·Journal of Dietary Supplements·Sreus A G NaiduA Satyanarayan Naidu
Apr 4, 2021·Microorganisms·Sophie I S Wedekind, Natalie S Shenker
Oct 21, 1999·Biochemical and Biophysical Research Communications·R SicilianoP Valenti
Oct 25, 2001·Antiviral Research·B W van der StrateD K Meijer
Nov 26, 2003·Antiviral Research·Tetsuya TanakaKei ichi Shimazaki
Oct 7, 2006·Antiviral Research·Maria Grazia AmmendoliaFabiana Superti
May 6, 2008·Antiviral Research·Håvard JenssenTore J Gutteberg

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