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Metal-coordinating substrate analogs as inhibitors of metalloenzymes

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 1979

B Holmquist, Bert L Vallee

PMID: 230502

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Abstract

A group of active-site metal coordinating inhibitors of zinc proteases (carboxypeptidase A, thermolysin, Bacillus cereus neutral protease, and angiotensin-converting enzyme) have been synthesized and their properties investigated. Their general structures are R-SH and R-NH-PO2(O phi)H, ...read more

Mentioned in this Paper

Angiotensin-Converting Enzyme Inhibitors
Circular Dichroism, Vibrational
Metalloproteins
Sulfhydryl Compounds
Cobalt
Protease Inhibitors
Spectrometry
Thermolysin
Carboxypeptidase
Paper Details
References
  • References26
  • Citations58
12345...

Metal-coordinating substrate analogs as inhibitors of metalloenzymes

Proceedings of the National Academy of Sciences of the United States of America

Dec 1, 1979

B Holmquist, Bert L Vallee

PMID: 230502

DOI:

Abstract

A group of active-site metal coordinating inhibitors of zinc proteases (carboxypeptidase A, thermolysin, Bacillus cereus neutral protease, and angiotensin-converting enzyme) have been synthesized and their properties investigated. Their general structures are R-SH and R-NH-PO2(O phi)H, ...read more

Mentioned in this Paper

Angiotensin-Converting Enzyme Inhibitors
Circular Dichroism, Vibrational
Metalloproteins
Sulfhydryl Compounds
Cobalt

Related Papers

Paper Details
References
  • References26
  • Citations58
12345...

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