Metal-dependent Deacetylases: Cancer and Epigenetic Regulators

ACS Chemical Biology
Jeffrey E LópezCarol A Fierke

Abstract

Epigenetic regulation is a key factor in cellular homeostasis. Post-translational modifications (PTMs) are a central focus of this regulation as they function as signaling markers within the cell. Lysine acetylation is a dynamic, reversible PTM that has garnered recent attention due to alterations in various types of cancer. Acetylation levels are regulated by two opposing enzyme families: lysine acetyltransferases (KATs) and histone deacetylases (HDACs). HDACs are key players in epigenetic regulation and have a role in the silencing of tumor suppressor genes. The dynamic equilibrium of acetylation makes HDACs attractive targets for drug therapy. However, substrate selectivity and biological function of HDAC isozymes is poorly understood. This review outlines the current understanding of the roles and specific epigenetic interactions of the metal-dependent HDACs in addition to their roles in cancer.

References

Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·C M GrozingerS L Schreiber
Oct 19, 1999·Molecular and Cellular Biology·A H WangX J Yang
Oct 6, 2000·Biochimica Et Biophysica Acta·U MahlknechtD Hoelzer
Aug 16, 2003·The Journal of Biological Chemistry·Ya-Li Yao, Wen-Ming Yang
Mar 5, 2004·Cancer Immunology, Immunotherapy : CII·A Nazmul H KhanThomas B Tomasi
Mar 26, 2004·The Prostate·Kalipso HalkidouCraig N Robson
Oct 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alessandro VanniniStefania Di Marco
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhenhuan ZhangHirotaka Iwase
Nov 30, 2004·Journal of Molecular Biology·Aidong HanLin Chen
Mar 17, 2005·Breast Cancer Research and Treatment·Claudia A KruscheJoachim Alfer
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Cécile CaronSaadi Khochbin
Mar 18, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·David WaltregnyVincent Castronovo
Sep 17, 2005·Molecular and Cellular Biology·Xuan ZhaoTso-Pang Yao
Nov 18, 2005·Gene·Michele A GlozakEdward Seto
Dec 17, 2005·The Journal of Biological Chemistry·Serge GrégoireXiang-Jiao Yang
May 2, 2007·Molecular and Cellular Biology·Silvia SeneseSusanna Chiocca
Sep 26, 2007·Journal of Neuroscience Research·Hedi LiuPing Ye
Oct 3, 2007·Cancer Research·Stephan ZimmermannMartin Göttlicher
Dec 12, 2007·Journal of Translational Medicine·A Nazmul H KhanThomas B Tomasi
Feb 23, 2008·Nature Reviews. Molecular Cell Biology·Xiang-Jiao Yang, Edward Seto
Jul 8, 2008·Biochimica Et Biophysica Acta·Brian C Smith, John M Denu
Jul 16, 2008·Molecular and Cellular Biology·Chengzhuo GaoHung-Ying Kao
Jul 18, 2008·Molecular Biology of the Cell·Andrew J WilsonJohn M Mariadason
Nov 18, 2008·Nature Immunology·Alejandro VillagraEduardo M Sotomayor
Dec 23, 2008·BMC Cancer·Florian R FritzscheGlen Kristiansen
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ina OehmeOlaf Witt
Mar 12, 2009·The Journal of Biological Chemistry·Michele A Glozak, Edward Seto
Jun 11, 2009·The Journal of Biological Chemistry·Xiaojuan SunRichard M Terek
Nov 18, 2009·Molecular and Cellular Biology·Simeen MalikSteffi Oesterreich
Dec 24, 2009·The Journal of Biological Chemistry·Stephanie L GanttCarol A Fierke

❮ Previous
Next ❯

Citations

Oct 22, 2016·Current Osteoporosis Reports·Alejandro Iglesias-LinaresJames Kennedy Hartsfield
Sep 21, 2017·Molecular Imaging·Brian P RempelChristopher P Phenix
Dec 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J PorterDavid W Christianson
Sep 4, 2020·Acta Crystallographica. Section F, Structural Biology Communications·Jeremy D Osko, David W Christianson
Dec 4, 2020·International Journal of Molecular Sciences·Yuxiang Luo, Huilin Li
Nov 5, 2017·Analytical Biochemistry·Tasha B ToroTerry J Watt
Jan 8, 2019·ACS Medicinal Chemistry Letters·Nicholas J PorterDavid W Christianson
Aug 18, 2018·Journal of Medicinal Chemistry·Nicholas J PorterDavid W Christianson
Dec 4, 2019·Journal of Medicinal Chemistry·Jeremy D OskoDavid W Christianson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.