Metal dyshomeostasis based biomarkers of lung cancer using human biofluids

Metallomics : Integrated Biometal Science
Belén Callejón-LeblicTamara García-Barrera

Abstract

Lung cancer (LC) is one of the most common causes of cancer-related deaths in the world and it is well known that trace elements play important roles in the carcinogenic process activating and inhibiting enzymatic reactions and metalloproteins, in which they usually participate as cofactors. A cross-sectional study was conducted on 48 lung cancer patients and 39 controls (56 men and 31 women), aged 44-76 years between March 2011 and June 2012. Eleven elements have been included in the study: V, Cr, Mn, Fe, Co, Cu, Zn, Se, Mo, Cd, and Pb, some of them considered toxic (V, Cd, Cr and Pb), while others are essential (Co, Mo, Se, Fe and Zn), and they have been analyzed by ICP-QQQ-MS in serum, urine and for the first time in bronchoalveolar lavage fluid (BALF). In order to understand the involvement of metals in this process, an analytical metallomic approach based on non-denaturing precipitation of proteins (NDPP) has been optimized for the fractionation of high molecular mass (HMM) and low molecular mass (LMM) metal species, in order to distinguish between metal species that affect the biological activity and toxicological potential of the elements. In this work, the NDPP followed by the analysis of metals by ICP-QQQ-MS has been a...Continue Reading

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Citations

Feb 15, 2019·International Journal of Molecular Sciences·Belén Callejón-LeblicTamara García-Barrera
Dec 19, 2019·Biological Trace Element Research·Muhammad Abdul QayyumDursun Kisa
Nov 21, 2020·International Journal of Molecular Sciences·Yan ZhangLin Zheng
Mar 27, 2021·Metallomics : Integrated Biometal Science·Liming WangChunying Chen

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Methods Mentioned

BETA
bronchoalveolar lavage
bronchoalveolar
lavage
atomic
X-ray
size-fractionation
g

Software Mentioned

STATISTICA
DA
PLS

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