Metal-free aerobic one-pot synthesis of substituted/annulated quinolines from alcohols via indirect Friedländer annulation

Organic & Biomolecular Chemistry
Namrata AnandMaya Shankar Singh

Abstract

Metal-free, operationally simple, and highly efficient one-pot aerobic process for the synthesis of functionalized/annulated quinolines is devised from easily available 2-aminobenzyl alcohol/2-aminobenzophenones and alkyl/aryl alcohols for the first time. The process involves two sequential reactions, namely in situ aerial oxidation of alcohols to the corresponding aldehydes/ketones followed by Friedländer annulation.

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Citations

Apr 26, 2019·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Andrea Porcheddu, Giorgio Chelucci
Jan 28, 2020·Current Organic Synthesis·Duc Dau Xuan
Dec 30, 2018·European Journal of Medicinal Chemistry·Lalit Mohan NainwalMohammad Mumtaz Alam
Apr 18, 2018·The Journal of Organic Chemistry·So Young LeeCheol-Hong Cheon

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