Metal Free C-H Functionalization Enabled Diastereoselective Multicomponent Reaction of N-Heterocycles to Fused Heteropolycycles

The Journal of Organic Chemistry
Sumana MandalChandan K Jana

Abstract

A novel C-H functionalization enabled multicomponent reaction involving N-heterocycles, dinucleophile, and dipolarophile has been developed. Direct α- and more challenging β-C(sp3)-H functionalization of aliphatic N-heterocycles was achieved without the use of metallic reagents and oxidants under either conventional or microwave aided heating conditions. In a single operation, up to five carbon-carbon and carbon-heteroatom bonds are formed in a highly diastereoselective manner, providing the expeditious access to the complex heteropolycycles.

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Citations

Feb 18, 2020·Chemical Communications : Chem Comm·Subhra Kanti RoyChandan K Jana
Nov 28, 2019·Organic & Biomolecular Chemistry·Santanu Ghosh, Chandan K Jana
Feb 27, 2019·The Journal of Organic Chemistry·Meng-Yang Chang, Yan-Shin Wu

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