Metal-free C-H mercaptalization of benzothiazoles and benzoxazoles using 1,3-propanedithiol as thiol source

Beilstein Journal of Organic Chemistry
Yan XiaoYajun Liu

Abstract

A facile and effective C-H functionalization strategy for the synthesis of 2-mercaptobenzothiazoles and 2-mercaptobenzoxazoles is described. 1,3-Propanedithiol was employed to convert benzothiazoles and benzoxazoles to the corresponding heteroarylthiols in the presence of potassium hydroxide and DMSO. This novel protocol is featured by direct C-H mercaptalization of heteroarenes and a simple reaction system.

References

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Citations

Jun 24, 2020·Chemical Communications : Chem Comm·Murat BozdagVincenzo Alterio

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Methods Mentioned

BETA
nuclear magnetic resonance
NMR

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