Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp(3) C-H Bond Activation

The Journal of Organic Chemistry
Jinwei SunYi Pan

Abstract

A versatile metal-free synthesis of allylic N-heterocycles has been developed using a TBAI/TBHP oxidation system. This general protocol could be applied for the C-N bond formation of electron-deficient phthalimides, imidazoles, triazoles, and sulfonamides with cyclic and acylic olefins. The practical use of the method is demonstrated by the amidation of functionalized biologically active substrates.

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Citations

Jan 20, 2016·Organic Letters·Calvin Q O'BroinKilian Muñiz
Mar 9, 2017·Organic Letters·Tomoaki YamaguchiAkichika Itoh
Mar 7, 2019·Organic & Biomolecular Chemistry·Yunlong Guo, Zengming Shen
Sep 4, 2019·Organic & Biomolecular Chemistry·Xin WangKai Sun
Jul 13, 2017·Chemical Reviews·Yan QinSanzhong Luo

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