Metal-free Regioselective Hydrochlorination of Unactivated Alkenes via a Combined Acid Catalytic System

Green Chemistry : an International Journal and Green Chemistry Resource : GC
Shengzong LiangBo Xu

Abstract

A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes. This hydrochlorination strategy is remarkably greener than previous reported methods in terms of high atom efficiency, no toxic waste generated and metal-free process. The higher efficiency, compared with other commercially available HCl reagents, was augmented by the good regioselectivity and functionality tolerance found. A stepwise mechanism for this hydrochlorination process was proposed based on kinetic studies.

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Citations

May 6, 2019·Organic Letters·Shengzong LiangGerald B Hammond

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Methods Mentioned

BETA
acetylation

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