Metal homeostasis in bacteria: the role of ArsR-SmtB family of transcriptional repressors in combating varying metal concentrations in the environment

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Rudra P SahaManoj Kumar Singh

Abstract

Bacterial infections cause severe medical problems worldwide, resulting in considerable death and loss of capital. With the ever-increasing rise of antibiotic-resistant bacteria and the lack of development of new antibiotics, research on metal-based antimicrobial therapy has now gained pace. Metal ions are essential for survival, but can be highly toxic to organisms if their concentrations are not strictly controlled. Through evolution, bacteria have acquired complex metal-management systems that allow them to acquire metals that they need for survival in different challenging environments while evading metal toxicity. Metalloproteins that controls these elaborate systems in the cell, and linked to key virulence factors, are promising targets for the anti-bacterial drug development. Among several metal-sensory transcriptional regulators, the ArsR-SmtB family displays greatest diversity with several distinct metal-binding and nonmetal-binding motifs that have been characterized. These prokaryotic metolloregulatory transcriptional repressors represses the expression of operons linked to stress-inducing concentrations of metal ions by directly binding to the regulatory regions of DNA, while derepression results from direct binding...Continue Reading

References

May 1, 1992·Journal of Bacteriology·R J TurnerD E Taylor
Jun 1, 1991·Molecular Microbiology·J Wu, B P Rosen
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C R WoeseM L Wheelis
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G NuciforaS Silver
Apr 1, 1968·Journal of Bacteriology·R P Novick, C Roth
Feb 1, 1995·Journal of Industrial Microbiology·J S Turner, N J Robinson
Jun 14, 1994·Biochemistry·T B GladyshevaB P Rosen
Aug 6, 1993·Science·T V O'Halloran
Apr 19, 1996·The Journal of Biological Chemistry·W ShiB P Rosen
Jun 1, 1996·FEMS Microbiology Letters·D F BruhnB P Rosen
Jun 12, 1996·Molecular & General Genetics : MGG·P BrünkerJ Altenbuchner
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·K Keyer, J A Imlay
Feb 1, 1997·Journal of Bacteriology·C NeytG R Cornelis
Apr 4, 1997·The Journal of Biological Chemistry·D Strausak, M Solioz
Nov 5, 1997·Applied and Environmental Microbiology·C L WangD S Clark
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·C RensingB P Rosen
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·C ThelwellJ S Turner-Cavet
Dec 4, 1998·American Journal of Infection Control·J B WrightR E Burrell

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Citations

Sep 24, 2020·Membranes·Andreea AndreiHans-Georg Koch
Dec 11, 2019·Extremophiles : Life Under Extreme Conditions·Dai-Di ChenWen-Jun Li
May 29, 2019·Journal of Structural Biology·Chandrasekaran PrabaharanSaravanamuthu Thiyagarajan
Sep 22, 2020·Trends in Microbiology·Giuliano T AnteloDaiana A Capdevila
Oct 28, 2019·Research in Microbiology·Marisol Goñi-UrrizaRémy Guyoneaud
Jul 30, 2019·International Journal of Biological Macromolecules·Giovanni GalloGabriella Fiorentino
Aug 14, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Anna RolaSławomir Potocki
Nov 17, 2021·Applied Biochemistry and Biotechnology·Shrute Kannappan, Bhaskar Chandra Mohan Ramisetty
Dec 2, 2021·Metallomics : Integrated Biometal Science·Luca MazzeiBarbara Zambelli

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Methods Mentioned

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