Metal ion homeostasis and intracellular parasitism

Molecular Microbiology
D D Agranoff, Sanjeev Krishna

Abstract

Bacteria possess multiple mechanisms for the transport of metal ions. While many of these systems may have evolved in the first instance to resist the detrimental effects of toxic environmental heavy metals, they have since become adapted to a variety of important homeostatic functions. The 'P'-type ATPases play a key role in metal ion transport in bacteria. A Cu+-ATPase from the intracellular bacterium Listeria monocytogenes is implicated in pathogenesis, and similar pumps in Mycobacterium tuberculosis and M. leprae may play a comparable role. Intracellular bacteria require transition metal cations for the synthesis of superoxide dismutases and catalases, which constitute an important line of defence against macrophage-killing mechanisms. The macrophage protein Nramp1, which confers resistance to a variety of intracellular pathogens, has also been shown recently to be a divalent amphoteric cation transporter. Mycobacterial homologues have recently been identified by genomic analysis. These findings suggest a model in which competition for divalent cations plays a pivotal role in the interaction between host and parasite.

References

Aug 1, 1977·The American Journal of Clinical Nutrition·W R Beisel
Nov 30, 1992·Annals of the New York Academy of Sciences·K AltendorfW Epstein
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G NuciforaS Silver
Apr 1, 1986·Antimicrobial Agents and Chemotherapy·W WitteS Silver
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·M CellierP Gros
Dec 5, 1995·Biochemistry·S Lutsenko, J H Kaplan
Jul 28, 1995·Science·R D FleischmannJ M Merrick
Oct 20, 1995·Science·C M FraserJ C Venter
Apr 21, 1995·The Journal of Biological Chemistry·Marc Solioz, A Odermatt
Oct 1, 1994·Journal of the American College of Nutrition·S K Roof, M E Maguire
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·L T PhungR Haselkorn
May 6, 1996·Biochimica Et Biophysica Acta·J V MøllerM le Maire
Jun 18, 1996·Biochemistry·K FendlerE Bamberg
Jan 1, 1996·Annual Review of Microbiology·S Silver, L T Phung
Jun 1, 1996·Trends in Genetics : TIG·M CellierP Gros
Nov 15, 1996·Nucleic Acids Research·R HimmelreichR Herrmann
Jan 27, 1997·Molecular & General Genetics : MGG·M S Francis, C J Thomas
Sep 5, 1997·Science·F R BlattnerY Shao
Mar 1, 1995·Trends in Cell Biology·D G Russell

Citations

Sep 22, 2001·International Journal for Parasitology·Sanjeev KrishnaC Woodrow
Dec 11, 1999·Molecular and Biochemical Parasitology·M KimuraH Ogura
Nov 20, 2004·Nature Reviews. Microbiology·Ulrich E Schaible, Stefan H E Kaufmann
Mar 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Oded LewinsonDouglas C Rees
Apr 25, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Bonnie Ransom SternTom Starr
Sep 8, 1999·The Journal of Experimental Medicine·Daniel AgranoffSanjeev Krishna
Apr 4, 2002·Journal of Pediatric Gastroenterology and Nutrition·Conor P DohertyAndrew M Prentice
Jul 4, 2001·Clinical Microbiology Reviews·J A Vázquez-BolandJ Kreft
Feb 16, 2002·Biochemical and Biophysical Research Communications·Martin Knöpfel, Marc Solioz
Jul 31, 2007·Future Microbiology·Scott R Waterman, Peter R Williamson
Mar 8, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Misha GolynskiySeth M Cohen
Jul 1, 2006·Critical Reviews in Microbiology·Sarita RanjanAkash Ranjan
Dec 4, 2012·The HUGO Journal·Umashankar VetrivelSudarsanam Dorairaj
Mar 23, 2007·Proteins·A Srinivas ReddyG Narahari Sastry
Sep 17, 2013·Molecular Oral Microbiology·A T Merchant, G A Spatafora
May 16, 2006·Immunobiology·Sek Tong OngJeak Ling Ding
Jun 28, 2003·FEMS Microbiology Reviews·Dayle K Blencowe, Andrew P Morby
May 15, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Andrés León-TorresCarlos-Y Soto
Aug 16, 2006·Biochimica Et Biophysica Acta·Yaniv Nevo, Nathan Nelson
Dec 22, 2009·Molecular BioSystems·Abeer FaddaKathleen Marchal
Jul 20, 2006·The Journal of Biological Chemistry·Elli RosenbergYaakov Pollack
Jan 22, 2015·The Journal of Biological Chemistry·Jonathan RosenbergFabian M Commichau
Jun 10, 2015·The Journal of Biological Chemistry·K Heran Darwin
Mar 7, 2014·The Journal of Biological Chemistry·Yixin ShiWei Kong
Feb 5, 2004·World Journal of Gastroenterology : WJG·Umit AksoySüleyman Yazar
Nov 27, 2019·Microorganisms·Chris Maltman, Vladimir Yurkov
Oct 22, 2020·Chemical Society Reviews·Nils KlöckerAndrea Rentmeister
Dec 15, 2020·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rabbul Ibne A Ahad, Mayashree B Syiem

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