Metal ion physiopathology in neurodegenerative disorders.

Neuromolecular Medicine
Silvia BologninPaolo Zatta

Abstract

Metal dyshomeostasis in the brain (BMD) has often been proposed as a possible cause for several neurodegenerative disorders (NDs). Nevertheless, the precise nature of the biochemical mechanisms of metal involvement in NDs is still largely unknown. Mounting evidence suggests that normal aging itself is characterized by, among other features, a significant degree of metal ion dysmetabolism in the brain. This is probably the result of a progressive deterioration of the metal regulatory systems and, at least in some cases, of life-long metal exposure and brain accumulation. Although alterations of metal metabolism do occur to some extent in normal aging, they appear to be highly enhanced under various neuropathological conditions, causing increased oxidative stress and favoring abnormal metal-protein interactions. Intriguingly, despite the fact that most common NDs have a distinct etiological basis, they share striking similarities as they are all characterized by a documented brain metal impairment. This review will primarily focus on the alterations of metal homeostasis that are observed in normal aging and in Alzheimer's disease. We also present a brief survey on BMD in other NDs (Amyotrophic Lateral Sclerosis, Parkinson's, and ...Continue Reading

References

Jan 22, 1976·The New England Journal of Medicine·A C AlfreyW D Kaehny
Aug 1, 1994·Biological Trace Element Research·A MoritaY Itokawa
Apr 1, 1993·Nature·P F Good, D P Perl
Jan 1, 1996·Gerontology·C Bertoni-FreddariW Meier-Ruge
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·T J LyonsJ S Valentine
Apr 1, 1997·Brain Research. Brain Research Reviews·M P Cuajungco, G J Lees
Jul 17, 1998·Journal of the Neurological Sciences·M A LovellW R Markesbery
Aug 26, 1998·Journal of Chemical Neuroanatomy·P ZambenedettiP Zatta
Aug 28, 1998·Journal of Neural Transmission·J A MolinaM C Martínez-Para
Sep 2, 1998·Proceedings of the National Academy of Sciences of the United States of America·K Pantopoulos, M W Hentze
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·S B Prusiner
Nov 5, 1999·The Biochemical Journal·D R BrownI M Jones
Mar 14, 2000·The Journal of Biological Chemistry·D J WaggonerD A Harris
Aug 10, 2000·Journal of the Neurological Sciences·M Said AhmedT Siddique
Oct 26, 2000·Trends in Pharmacological Sciences·J H WeissJ Y Koh
Oct 29, 2000·Biological Trace Element Research·L L RulonW R Markesber
Feb 7, 2002·The Biochemical Journal·Alana M ThackrayDavid R Brown
Mar 13, 2002·Nature Neuroscience·Jamuna R SubramaniamPhilip C Wong
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joo-Yong LeeJae-Young Koh
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Jack T RogersSteven R Gullans
Oct 9, 2002·Journal of Pediatric Hematology/oncology·Mark B SalzmanCharles Koo
Dec 31, 2002·Brain Research. Brain Research Reviews·Math P Cuajungco, Kyle Y Fagét
Apr 12, 2003·Trends in Neurosciences·Ashley I Bush
Apr 22, 2003·Journal of Neuroscience Research·Atsushi TakedaNaoto Oku

❮ Previous
Next ❯

Citations

Feb 20, 2013·Molecular Neurobiology·Neha Singla, D K Dhawan
Aug 5, 2010·European Journal of Human Genetics : EJHG·Arianna TucciCoro Paisán-Ruiz
Jan 7, 2011·Metallomics : Integrated Biometal Science·Ebany J Martinez-FinleyMichael Aschner
Aug 9, 2013·Chemical Communications : Chem Comm·Adriana BadarauChristopher Dennison
Mar 29, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Raúl González-DomínguezJosé Luis Gómez-Ariza
Mar 19, 2014·Neurotoxicology·Martje W G D M de Groot, Remco H S Westerink
Mar 1, 2011·The FEBS Journal·Jonathan Martínez-FábregasMiguel Á De la Rosa
May 13, 2015·Biochimica Et Biophysica Acta·Jaime Cárcel-TrullolsDavid A Pearce
May 6, 2015·Biochimica Et Biophysica Acta·Kiterie M E FallerMichael Bond
Aug 29, 2013·Oxidative Medicine and Cellular Longevity·Yan Zhao, Baolu Zhao
Jun 1, 2011·Biomolecular Concepts·Vilmante BorutaiteGintaras Valincius
Mar 23, 2012·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Lilian Calderón-GarcidueñasTomás R Guilarte
Mar 8, 2011·The International Journal of Biochemistry & Cell Biology·Silvia BologninPaolo Zatta
Dec 12, 2012·Neurochemistry International·Claudia FunkeDouglas B Kell
Jun 8, 2014·The Science of the Total Environment·F AmatoX Querol
May 27, 2014·Frontiers in Aging Neuroscience·Alberto Granzotto, Paolo Zatta
Apr 23, 2011·Journal of Pharmacological Sciences·Yanier Núñez FigueredoGilberto L Pardo Andreu
Jun 14, 2016·Parkinson's Disease·Yorka MuñozMarco T Núñez
Feb 9, 2017·Metallomics : Integrated Biometal Science·Stuart D PortburyPaul A Adlard
Dec 17, 2014·Inorganic Chemistry·Riccardo De RiccoStefano Mangani
Dec 23, 2015·Metallomics : Integrated Biometal Science·Stuart D PortburyPaul A Adlard
Jan 6, 2015·Chemical Society Reviews·Xuhong Qian, Zhaochao Xu
Aug 10, 2017·Reviews in the Neurosciences·Sotirios Apostolakis, Anna-Maria Kypraiou
Aug 25, 2015·Chemistry : a European Journal·Valentina OliveriGraziella Vecchio
Sep 25, 2018·Metallomics : Integrated Biometal Science·Iñaki GentileClaudio O Fernández
Feb 20, 2018·Molecular and Cellular Biochemistry·Kentaro Oh-HashiYoko Hirata
Feb 24, 2015·Biofizika·Yu M Harmasa, E I Slobozhanina
Nov 20, 2013·Metallomics : Integrated Biometal Science·Masahiro KawaharaYutaka Sadakane
May 8, 2014·Metallomics : Integrated Biometal Science·Alexandra GrubmanKatja M Kanninen
Mar 19, 2019·Frontiers in Neuroscience·Alain NdayisabaGregor K Wenning
Mar 29, 2011·Metallomics : Integrated Biometal Science·Masahiro KawaharaYutaka Sadakane
Jan 18, 2019·Molecular Neurodegeneration·Anil B MukherjeeMaria B Bagh
Jul 13, 2019·Nutrients·Francisco José Sánchez-MunizMaría José González-Muñoz
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Cezary GrochowskiPrzemysław Niedzielski
Dec 19, 2019·Environmental Science and Pollution Research International·Fatemeh Faraji GhasemiMozhgan Keshtkar
Apr 24, 2012·Journal of Toxicology·Sermin GencKursad Genc
Mar 17, 2015·Chembiochem : a European Journal of Chemical Biology·Jeffrey S Derrick, Mi Hee Lim
Aug 12, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Daphne S CukiermanNicolás A Rey
Jul 7, 2020·Chemistry : a European Journal·Francesco BelliaGraziella Vecchio

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Prions

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion-like mechanisms are associated with the pathogenesis of Amyotrophic Lateral Sclerosis (ALS). Here is the latest research on ALS and prions.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.