Metal-Mediated Halogen Exchange in Aryl and Vinyl Halides: A Review

Frontiers in Chemistry
Gwilherm EvanoDamien F Dewez

Abstract

Halogenated arenes and alkenes are of prime importance in many areas of science, especially in the pharmaceutical, agrochemical, and chemical industries. While the simplest ones are commercially available, some of them are still hardly accessible depending on their substitution patterns and the nature of the halogen atom. Reactions enabling the selective and efficient replacement of the halogen atom of an aryl or alkenyl halide by another one, lighter, or heavier, are therefore of major importance since they can be used for example to turn a less reactive aryl/alkenyl chloride into the more reactive iodinated derivatives or, in a reversed sense, to block an undesired reactivity, for late-stage modifications or for the introduction of a radionuclide. If some halogen exchange reactions are possible with activated substrates, they usually require catalysis with metal complexes. Remarkably efficient processes have been developed for metal-mediated halogen exchange in aryl and vinyl halides: they are overviewed, in a comprehensive manner, in this review article.

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Citations

Aug 15, 2019·Angewandte Chemie·Julie L HofstraSarah E Reisman
Oct 11, 2019·Beilstein Journal of Organic Chemistry·Xiaowei LiDayong Shi
Nov 12, 2019·Journal of the American Chemical Society·L Reginald MillsSophie A L Rousseaux
Jan 23, 2021·Angewandte Chemie·Alexander FawcettJohn F Hartwig
Mar 31, 2021·Chemistry : a European Journal·Patrick ZimdarsPeter Metz
May 24, 2019·Organic Letters·Antoine NiteletGwilherm Evano

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BETA
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