Metal-on-polyethylene versus metal-on-metal bearing surfaces in total hip arthroplasty: a prospective randomised study investigating metal ion levels and chromosomal aberrations in peripheral lymphocytes

The Bone & Joint Journal
T W R BriggsR W J Carrington

Abstract

The long term biological effects of wear products following total hip arthroplasty (THA) are unclear. However, the indications for THA are expanding, with increasingly younger patients undergoing the procedure. This prospective, randomised study compared two groups of patients undergoing THA after being randomised to receive one of two different bearing surfaces: metal-on-polyethylene (MoP) n = 22 and metal-on-metal (MoM) n = 23. We investigated the relationship between three variables: bearing surface (MoP vs MoM), whole blood levels of chromium (Cr) and cobalt (Co) and chromosomal aberrations in peripheral lymphocyte pre-operatively and at one, two and five years post-surgery. Our results demonstrated significantly higher mean cobalt and chromium (Co and Cr) blood levels in the MoM group at all follow-up points following surgery (p < 0.01), but there were no significant differences in the chromosomal aberration indices between MoM and MoP at two or five years (two years: p = 0.56, p = 0.08, p = 0.91, p = 0.51 and five years: p = 0.086, p = 0.73, p = 0.06, p = 0.34) for translocations, breaks, loss and gain of chromosomes respectively. Regression analysis showed a strong linear relationship between Cr levels and the total chro...Continue Reading

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Citations

Dec 6, 2008·The Journal of Arthroplasty·Ehab AldlyamiPaul F Partington
Aug 3, 2016·Haemophilia : the Official Journal of the World Federation of Hemophilia·A C StraussJ Schmolders
Jan 27, 2017·Acta Orthopaedica·Minna LaitinenAntti Eskelinen
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May 4, 2021·The Spine Journal : Official Journal of the North American Spine Society·Daniel CobanArash Emami

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