Metal Organic Framework (MOF) Particles as Potential Bacteria-Mimicking Delivery Systems for Infectious Diseases: Characterization and Cellular Internalization in Alveolar Macrophages

Pharmaceutical Research
Ailin GuoJoshua Reineke

Abstract

Intramacrophagic bacteria pose a great challenge for the treatment of infectious diseases despite many macrophage targeted drug delivery approaches explored. The use of biomimetic approaches for treating infectious diseases is promising, but not studied extensively. The study purpose is to evaluate iron-based metal-organic frameworks (MOF) as a potential bacteria-mimicking delivery system for infectious diseases. Two types of carboxylated MOFs, MIL-88A(Fe) and MIL-100(Fe) were developed as "pathogen-like" particles by surface coating with mannose. MOF morphology, cellular uptake kinetics, and endocytic mechanisms in 3D4/21 alveolar macrophages were characterized. MIL-88A(Fe) is rod-shape (aspect ratio 1:5) with a long-axis size of 3628 ± 573 nm and MIL-100(Fe) is spherical with diameter of 103.9 ± 7.2 nm. Cellular uptake kinetics of MOFs showed that MIL-100(Fe) nanoparticles were internalized at a faster rate and higher extent compared to MIL-88A(Fe) microparticles. Mannosylation did not improve the uptake of MIL-100(Fe) particles, whereas it highly increased MIL-88A(Fe) cellular uptake and number of cells involved in internalization. Cell uptake inhibition studies indicated that macropinocytosis/phagocytosis was the main endoc...Continue Reading

References

Oct 29, 1987·Biochemical and Biophysical Research Communications·J D Stephenson, V L Shepherd
Jun 1, 1974·Journal of Bacteriology·J L HartleyT G Tornabene
Mar 1, 1981·Reviews of Infectious Diseases·C J LeeK T Lin
Jun 9, 1999·The Journal of Laboratory and Clinical Medicine·R VassalloA H Limper
May 11, 2000·Journal of Inorganic Biochemistry·L C KönigsbergerG T Hefter
Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Julie A Champion, Samir Mitragotri
Apr 1, 2008·Pharmaceutical Research·Julie A ChampionSamir Mitragotri
Jul 17, 2008·Journal of the American Chemical Society·Alistair C McKinlayRussell E Morris
Apr 23, 2009·Chemical Society Reviews·JeongYong LeeJoseph T Hupp
Apr 23, 2009·Chemical Society Reviews·Jian-Rong LiHong-Cai Zhou
Jun 17, 2009·Cell Host & Microbe·Yadunanda Kumar, Raphael H Valdivia
Oct 8, 2009·Journal of the American Chemical Society·Kathryn M L Taylor-PashowWenbin Lin
Jan 15, 2010·Current Opinion in Chemical Biology·Rachel C HuxfordWenbin Lin
Jun 18, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Murugesan V S RajaramLarry S Schlesinger
Jul 24, 2010·Angewandte Chemie·Alistair C McKinlayChristian Serre
Sep 28, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hua YueZhiguo Su
Jul 2, 2011·Nature Reviews. Drug Discovery·Jin-Wook YooSamir Mitragotri
Dec 16, 2011·Chemical Reviews·Patricia HorcajadaChristian Serre
Jan 28, 2012·Chemical Reviews·Hong-Cai ZhouOmar M Yaghi
Jun 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Poornima KolharSamir Mitragotri
Jun 19, 2013·Advanced Healthcare Materials·Valentina AgostoniRuxandra Gref
Jan 5, 2014·Nano Letters·Sabyasachi DasguptaGerhard Gompper
May 17, 2014·Current Opinion in Biotechnology·Joseph A RosenthalMatthew P DeLisa
Sep 24, 2014·Experimental Cell Research·Ilaria FiorentinoRiccardo Talevi
Nov 11, 2014·Beilstein Journal of Nanotechnology·Dagmar A KuhnBarbara Rothen-Rutishauser
Dec 17, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Brijeshkumar PatelFakhrul Ahsan
Jun 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yolandy LemmerChantal de Chastellier
Nov 3, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hagar Ibrahim LaboutaClaus-Michael Lehr
Dec 8, 2015·Nano Today·Heather Herd GustafsonHamidreza Ghandehari
Jul 8, 2016·Advanced Healthcare Materials·Claudia Orellana-TavraDavid Fairen-Jimenez
Mar 23, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mojgan SheikhpourAlibakhsh Kasaeian

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Citations

Aug 18, 2020·Chemical Communications : Chem Comm·Jun HuGaojian Chen
Mar 13, 2019·Pharmaceutical Research·Admire Dube
Jan 22, 2021·Advanced Healthcare Materials·Arezoo EsrafiliAbhinav P Acharya
Sep 25, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Iqra GhaffarMuhammad Raza Shah
Jul 6, 2021·RSC Medicinal Chemistry·Yiwei LiuJianqiang Liu
Aug 10, 2021·ACS Applied Bio Materials·Maya HolayLiangfang Zhang

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Methods Mentioned

BETA
X-ray
dynamic light scattering
flow cytometry

Software Mentioned

ImageJ
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