Metal-Organic Framework/Ag-Based Hybrid Nanoagents for Rapid and Synergistic Bacterial Eradication

ACS Applied Materials & Interfaces
Ye YangChangsheng Zhao

Abstract

Recent emerged metal-organic frameworks (MOFs), as superior drug carriers, provide novel strategies to combat pathogenic bacterial infections. Although various antibacterial metal ions can be easily introduced in MOFs for chemical bacterial ablation, such a single-model bactericidal method suffers from high-dose use, limited antibacterial efficiency, and slow sterilization rate. Hence, developing a dual bactericidal system is urgently required. Herein, we report an MOF/Ag-derived nanocomposite with efficient metal-ion-releasing capability and robust photo-to-thermal conversion effect for synergistic sterilization. The MOF-derived nanocarbon consisting of metallic zinc and a graphitic-like carbon framework is first synthesized, and then Ag nanoparticles (AgNPs) are evenly introduced via the displacement reaction between Zn and Ag+. Upon near-infrared irradiation, the fabricated nanoagents can generate massive heat to destroy bacterial membranes. Meanwhile, abundant Zn2+ and Ag+ ions are released to make chemical damage to bacterial intracellular substances. Systematic antibacterial experiments reveal that such dual-antibacterial effort can endow the nanoagents with nearly 100% bactericidal ratio for highly concentrated bacteria ...Continue Reading

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Citations

Oct 31, 2020·Advanced Materials·Lang MaLi Qiu
Feb 11, 2021·Biomaterials Science·Minjie XuQinglian Hu
Jan 27, 2021·ACS Nano·Joshua SeabergPriyabrata Mukherjee
Mar 23, 2021·Advanced Materials·Ben ZhangChong Cheng
May 18, 2021·Journal of Inorganic and Organometallic Polymers and Materials·Pierre D Harvey, Jessica Plé
Jul 6, 2021·RSC Medicinal Chemistry·Yiwei LiuJianqiang Liu
Jul 4, 2021·Advanced Materials·Xin FanRainer Haag

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