Metal-Organic Frameworks: A Potential Platform for Enzyme Immobilization and Related Applications

Frontiers in Bioengineering and Biotechnology
Huan XiaYanbin Jiang

Abstract

Enzymes, as natural catalysts with remarkable catalytic activity and high region-selectivities, hold great promise in industrial catalysis. However, applications of enzymatic transformation are hampered by the fragility of enzymes in harsh conditions. Recently, metal-organic frameworks (MOFs), due to their high stability and available structural properties, have emerged as a promising platform for enzyme immobilization. Synthetic strategies of enzyme-MOF composites mainly including surface immobilization, covalent linkage, pore entrapment and in situ synthesis. Compared with free enzymes, most immobilized enzymes exhibit enhanced resistance against solvents and high temperatures. Besides, MOFs serving as matrixes for enzyme immobilization show extraordinary superiority in many aspects compared with other supporting materials. The advantages of using MOFs to support enzymes are discussed. To obtain a high enzyme loading capacity and to reduce the diffusion resistance of reactants and products during the reaction, the mesoporous MOFs have been designed and constructed. This review also covers the applications of enzyme-MOF composites in bio-sensing and detection, bio-catalysis, and cancer therapy, which is concerned with interdis...Continue Reading

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Citations

Feb 6, 2021·Analytical Methods : Advancing Methods and Applications·Huifei ZhongRui Zhao
Nov 10, 2020·Frontiers in Bioengineering and Biotechnology·Chan Hee LeeEe Taek Hwang
Mar 5, 2021·ACS Applied Materials & Interfaces·Maya MolcoAmit Sitt
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reem ShomalSulaiman Al-Zuhair
Jul 9, 2021·International Journal of Biological Macromolecules·Ahmet Ulu, Burhan Ateş
Aug 15, 2021·Journal of Environmental Management·Sufia Ul Haque Inamuddin

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Methods Mentioned

BETA
chemical modification
biosensing
ABTS
dynamic light scattering

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