Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Pharmaceutics
Mengru CaiXingbin Yin

Abstract

: In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the effic...Continue Reading

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Citations

Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
Apr 4, 2021·International Journal of Molecular Sciences·Sihan FengNaoki Kano
Apr 30, 2021·Expert Opinion on Therapeutic Patents·José Marcos Teixeira de Alencar FilhoLarissa Araújo Rolim
Jun 22, 2021·Food & Function·Xinlong ZangXuehong Chen
Jun 25, 2021·Chemical Science·Corey R MartinNatalia B Shustova

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Methods Mentioned

BETA
fluorescence imaging
Scanning Microscopy

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