Metal oxide nanoparticles for latent fingerprint visualization and analysis of small drug molecules using surface-assisted laser desorption/ionization mass spectrometry

Analytical and Bioanalytical Chemistry
Mohamed O AminEntesar Al-Hetlani

Abstract

We explored the applicability of different metal oxide nanoparticles (NPs; ZnO, TiO2, Fe2O3, and CeO2) for the optical imaging and mass spectrometric determination of small drug molecules in latent fingerprints (LFPs). Optical imaging was achieved using a dry method-simply dusting the LFPs with a minute amount of NP powder-and still images were captured using a digital microscope and a smartphone camera. Mass spectrometric determination was performed using the NPs as substrates for surface-assisted laser desorption ionization/mass spectrometry (SALDI-MS), which enabled the detection of small drug molecules with high signal intensities. The reproducibility of the results was studied by calculating the % error, SD, and RSD in the results obtained with the various metal oxide NPs. Collectively, the findings showed that using NPs can boost the intensity of the detected signal while minimizing background noise which is an issue predominantly associated with conventional organic matrices of MALDI-MS. Among the four metal oxide NPs, utilization of the Fe2O3 NPs led to the best SALDI performance and the highest detection sensitivity for the analytes of interest. The study was then extended by investigating the influence of time elapsed...Continue Reading

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Citations

Sep 27, 2018·Journal of Food and Drug Analysis·Han-Wei ChuChih-Ching Huang
Feb 17, 2019·Nanomaterials·Pawel Pomastowski, Boguslaw Buszewski
Mar 17, 2020·Journal of Forensic Sciences·Marina GonzálezRenata Pereira Limberger
Jan 2, 2021·Forensic Science International : Synergy·Andy BécueChristophe Champod

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