PMID: 2484580Jul 1, 1989Paper

Metal-protein interactions in transport, accumulation, and excretion of metals

Biological Trace Element Research
B Sarkar

Abstract

The binding of Cu(II), Zn(II), Ni(II), and Cd(II) to protein components in serum, placenta, kidney, and urine was investigated at physiological pH, using radioisotopes as tracers. All the four metals were bound to albumin and other macromolecules in serum. However, small amounts were also bound to low molecular weight components of the size 1500-10000 daltons. The nature of the Cu(II)-binding to alpha-fetoprotein suggests its important role as the Cu(II)-transporting protein in fetal life. Metal binding to placental components were studied using both rat placenta and isolated human trophoblast cells. Studies of metal binding targets in kidney resulted in the isolation of a 4000 daltons acidic polypeptide which binds Ni(II) and Cd(II) with Kapp = 1.1 x 10(-5) and 2.3 x 10(-5), respectively. Studies of metal binding substances in urine reveals the major amounts of these metals binding to substances of molecular weight 500-5000 daltons. Preliminary amino acid analysis suggests these components rich in acidic amino acids, similar to what has been found with kidney polypeptide. There may be a general role for such compounds in the handling of metals in the process of excretion.

References

Aug 1, 1976·The American Journal of Clinical Nutrition·G W Evans, B L Reis
Dec 1, 1988·Biological Trace Element Research·A Mas, B Sarkar
Jun 1, 1984·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·S J Lau, B Sarkar
May 1, 1955·The American Journal of Physiology·J P FEASTERG K DAVIS
Oct 1, 1961·The Journal of Clinical Investigation·I SternliebI H Scheinberg

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Citations

Nov 1, 1994·Journal of Biomedical Materials Research·J Yang, K Merritt
Jul 2, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·R KäkeläH Hyvärinen
Feb 12, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Pijus K SasmalAkhil R Chakravarty
Nov 13, 2010·Metallomics : Integrated Biometal Science·Sounik SahaAkhil R Chakravarty
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·G C DismukesA Tyryshkin
Jan 1, 1991·Drug Metabolism Reviews·N Ballatori
Feb 6, 2007·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Adal T AbebeWilliam E Robinson
Nov 4, 2015·ACS Applied Materials & Interfaces·Shyam SarkarVenkataramanan Mahalingam
Jan 27, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Katherine H Thompson, Chris Orvig
Aug 23, 2018·Metallomics : Integrated Biometal Science·Amélie I S SobczakAlan J Stewart
May 1, 2012·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Anna KalafovaTomasz Laciak
Aug 1, 1996·Clinical Orthopaedics and Related Research·K Merritt, S A Brown
Mar 10, 2009·Inorganic Chemistry·Sounik SahaAkhil R Chakravarty
Aug 3, 2005·Inorganic Chemistry·Andriy MokhirRoland Kraemer
Feb 10, 2009·Journal of Inorganic Biochemistry·Daniele SannaGiovanni Micera

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