Metal-responsive transcription factor-1 (MTF-1) is essential for embryonic liver development and heavy metal detoxification in the adult liver

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Ying WangW Schaffner

Abstract

Metal-responsive transcription factor-1 (MTF-1) activates the transcription of metallothionein genes and other target genes in response to heavy metal load and other stresses such as hypoxia and oxidative stress. It also has an essential function during embryogenesis: targeted disruption of Mtf1 in the mouse results in lethal liver degeneration on day 14 of gestation. Here we studied Mtf1 knockout mice at embryonic and adult stages, the latter by means of conditional knockout. Hepatocytes from Mtf1 null mutant and wild-type embryos were taken into culture on day 12.5 of gestation. Both initially appeared normal, but mutant cells were lost within a few days. Furthermore, Mtf1 null hepatocytes were poorly, if at all, rescued by cocultivation with wild-type rat embryo hepatocytes, indicating a cell-autonomous defect. When the Mtf1 gene was excised by Cre recombinase after birth in liver and bone marrow and to a lesser extent in other organs, mice were viable under non-stress conditions but highly susceptible to cadmium toxicity, in support of a role of MTF-1 in coping with heavy metal stress. An additional MTF-1 function was revealed upon analysis of the hematopoietic system in conditional knockout mice where leukocytes, especiall...Continue Reading

References

Feb 1, 1972·The Biochemical Journal·G F NordbergO Vesterberg
Sep 8, 1995·Science·R KühnK Rajewsky
Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·B A MastersR D Palmiter
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A E Michalska, K H Choo
Jan 1, 1997·The Tohoku Journal of Experimental Medicine·N Shiojiri, T Koike
Apr 1, 1998·Developmental Biology·S Giroux, J Charron
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·S GaniatsasL I Zon
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R D Palmiter
Oct 28, 1998·Trends in Cell Biology·C Birchmeier, E Gherardi
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J P SchofieldM Wakamiya
Jan 25, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J PlümpeC Trautwein
Mar 8, 2000·Mechanisms of Development·K S Zaret
Aug 23, 2000·The Journal of Biological Chemistry·S J LangmadeG K Andrews
Dec 20, 2000·The Journal of Investigative Dermatology·P M LacalS D'Atri
Mar 27, 2001·Nucleic Acids Research·P LichtlenW Schaffner
Sep 5, 2001·Current Opinion in Genetics & Development·A B Cantor, S H Orkin
Sep 5, 2001·Current Opinion in Genetics & Development·K S Zaret
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Lichtlen, W Schaffner

❮ Previous
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Citations

Oct 14, 2005·Nucleic Acids Research·Ursula WimmerWalter Schaffner
Jul 2, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Steven O SimmonsRam Ramabhadran
Jul 5, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jia ShaoOscar L Volger
Mar 9, 2011·Molecular and Cellular Biology·Nidhi SainiWalter Schaffner
Apr 30, 2009·Annual Review of Nutrition·Louis A Lichten, Robert J Cousins
Jan 27, 2007·BMC Bioinformatics·Manisha BrahmacharyVladimir B Bajic
Sep 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Juan P LiuzziRobert J Cousins
May 13, 2014·American Journal of Respiratory Cell and Molecular Biology·Koustav GangulyGeorge D Leikauf
Jun 16, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ivan SabolićCarol M Herak-Kramberger
Mar 13, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Scott FaberH M Skip Kingston
Oct 12, 2010·Ageing Research Reviews·William R Swindell
May 24, 2006·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Dieter EgliSílvia Atrian
Aug 29, 2006·Biochimie·J-P BourdineaudJ-L Moreau
Apr 23, 2014·Biochimica Et Biophysica Acta·Britton O'ShieldsMatthew J Jenny
Feb 1, 2012·Biochimica Et Biophysica Acta·Viola GüntherWalter Schaffner
Apr 14, 2016·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Katharina SchmidtWalter Schaffner
Apr 12, 2007·International Review of Cytology·Naoki Tanimizu, Atsushi Miyajima
Feb 14, 2015·Current Opinion in Cell Biology·Robert Schinzel, Andrew Dillin
Dec 7, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tomoki Kimura
May 17, 2018·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Michael Francis, Arthur Grider
Jan 10, 2018·Frontiers in Genetics·Juan A Navarro, Stephan Schneuwly
Apr 19, 2006·Journal of Cellular Biochemistry·Tomoki KimuraMasakazu Isobe
Apr 9, 2008·Genesis : the Journal of Genetics and Development·Taiho KambeGlen K Andrews
Nov 17, 2006·The Journal of Biological Chemistry·David J AdleJaekwon Lee
Aug 27, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Lilit AtanesyanWalter Schaffner
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cristina Tavera-MontañezTeresita Padilla-Benavides
Mar 14, 2012·G3 : Genes - Genomes - Genetics·Kai Li TanSvetlana Minakhina
Feb 11, 2015·Metallomics : Integrated Biometal Science·Eszter EmriGabriella Emri

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