Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]

Chemistry : a European Journal
Isabel FuentesClara Viñas

Abstract

After uptake by U87 MG and A375 cancer cells, cobaltabisdicarbollide [COSAN]- distributes between membrane and nucleus and presents no relevant cytotoxicity against both cell lines even for long incubation times. The cytotoxicity of Na[COSAN] was also tested towards one normal cell line, the V79 fibroblasts, in order to ascertain the noncytotoxic profile of the compound. As the cell's nucleus contains DNA, the interaction between [COSAN]- and double-stranded calf thymus DNA (CT-dsDNA) has been investigated. There is a strong interaction between both molecules forming a nanohybrid CT-dsDNA-[COSAN] biomaterial, which was fully characterized. Moreover, Na[COSAN] shows characteristic redox peaks ascribed to the oxidation/reduction of Co3+/2+ at a formal potential of -1.444 V and it can be accumulated at a surface-immobilized DNA layer of glassy carbon electrodes. The equilibrium surface-binding constants (Kox /Kred ), which confirm that [COSAN]- interacts with DNA by an intercalative or electrostatic mode, depending on the ionic strength of the solution, were estimated. In addition, high binding affinity of Na[COSAN] to proteins was observed by 11 B{1 H} NMR and confirmed in vivo. Finally, biodistribution studies of [COSAN]- in nor...Continue Reading

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Citations

Aug 15, 2019·Chemistry : a European Journal·Isabel FuentesFrancesc Teixidor
Aug 18, 2020·Cancer Communications·Mayya Alexandrovna DymovaElena Vladimirovna Kuligina
Jul 7, 2020·Chemistry : a European Journal·Tania MerhiPierre Bauduin
Apr 23, 2020·Future Medicinal Chemistry·Anastasija A IgnatovaAlexey V Feofanov
Jul 9, 2020·Chemical Communications : Chem Comm·Marcos NavascuezJordi Llop
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Aug 14, 2019·Annals of the New York Academy of Sciences·Krzysztof FinkTomasz M Goszczyński
Jun 11, 2020·Chemistry : a European Journal·Vladimir I BregadzeNarayan S Hosmane
Jan 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna A DruzinaVladimir I Bregadze
Jan 29, 2021·ChemMedChem·Marta GozziEvamarie Hey-Hawkins
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Oct 26, 2021·Inorganic Chemistry·Ana B BuadesFrancesc Teixidor

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