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Metallic gold reduces TNFalpha expression, oxidative DNA damage and pro-apoptotic signals after experimental brain injury

Brain Research

Mar 31, 2009

Mie Ostergaard PedersenM Penkowa

Abstract

Brain injury represents a major health problem and may result in chronic inflammation and neurodegeneration. Due to antiinflammatory effects of gold, we have investigated the cerebral effects of metallic gold particles following a focal brain injury (freeze-lesion) in mice. Gold particl...read more

Mentioned in this Paper

Guanine
Larsen Syndrome
Brain Injuries
Mild Traumatic Brain Injury
Immunohistochemistry
Tumor Necrosis Factor-alpha
8-oxyguanine
Apoptosis, Intrinsic Pathway
Enzymes, antithrombotic
Apocytochrome C
Paper Details
References
  • References58
  • Citations9
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  • References58
  • Citations9
1

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Metallic gold reduces TNFalpha expression, oxidative DNA damage and pro-apoptotic signals after experimental brain injury

Brain Research

Mar 31, 2009

Mie Ostergaard PedersenM Penkowa

PMID: 19328189

DOI: 10.1016/j.brainres.2009.03.022

Abstract

Brain injury represents a major health problem and may result in chronic inflammation and neurodegeneration. Due to antiinflammatory effects of gold, we have investigated the cerebral effects of metallic gold particles following a focal brain injury (freeze-lesion) in mice. Gold particl...read more

Mentioned in this Paper

Guanine
Larsen Syndrome
Brain Injuries
Mild Traumatic Brain Injury
Immunohistochemistry
Tumor Necrosis Factor-alpha
8-oxyguanine
Apoptosis, Intrinsic Pathway
Enzymes, antithrombotic
Apocytochrome C

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Astrocytes and Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

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Paper Details
References
  • References58
  • Citations9
12345...
  • References58
  • Citations9
1
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