Metallic nanohole arrays on fluoropolymer substrates as small label-free real-time bioprobes.

Nano Letters
Jiun-Chan YangDale N Larson

Abstract

We describe a nanoplasmonic probing platform that exploits small-dimension (<or=20 microm (2)) ordered arrays of subwavelength holes for multiplexed, high spatial resolution, and real-time analysis on biorecognition events. Nanohole arrays are perforated on a super smooth gold surface (roughness rms < 2.7 A) attached on a fluoropolymer (FEP) substrate fabricated by a replica technique. The smooth surface of gold provides a superb environment for fabricating nanometer features and uniform immobilization of biomolecules. The refractive index matching between FEP and biological solutions contributes to approximately 20% improvement on the sensing performance. Spectral studies on a series of small-dimension nanohole arrays from 1 microm (2) to 20 microm (2) indicate that the plasmonic sensing sensitivity improves as the gold-solution contact area increases. Our results also demonstrate that nanohole arrays with a dimension as small as 1 microm (2) can be used to effectively detect biomolecular binding events and analyze the binding kinetics. The future scientific opportunities opened by this nanohole platform include highly multiplexed analysis of ligand interactions with membrane proteins on high quality supported lipid bilayers.

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Citations

Feb 18, 2009·Analytical and Bioanalytical Chemistry·Abraham J QaviRyan C Bailey
Dec 12, 2012·Analytical Chemistry·Shailabh KumarSang-Hyun Oh
Aug 17, 2011·ACS Nano·Nathan J WittenbergSang-Hyun Oh
Nov 8, 2011·Nature Photonics·Xudong Fan, Ian M White
Jul 14, 2012·Reports on Progress in Physics·Nathan C LindquistSang-Hyun Oh
Apr 22, 2014·Chemical Reviews·Onur TokelUtkan Demirci
Mar 22, 2014·Nano Letters·Avijit BarikSang-Hyun Oh
Feb 25, 2015·Scientific Reports·Kuang-Li LeePei-Kuen Wei
Jan 23, 2009·Biosensors & Bioelectronics·Jiun-Chan YangDale N Larson
Mar 9, 2017·Biomedical Optics Express·Brenda DohertyMarkus A Schmidt
Apr 7, 2017·Chemical Society Reviews·Joshua A JackmanNam-Joon Cho
Nov 18, 2009·Biotechnology Journal·Jennifer A MaynardSang-Hyun Oh
Dec 10, 2009·Optics Express·Qiaoqiang GanFilbert J Bartoli
Oct 14, 2009·Optics Letters·Qiaoqiang Gan, Filbert J Bartoli
Feb 22, 2012·Optics Letters·Qing TanHans Peter Herzig
May 5, 2009·Analytical Chemistry·Fatemeh EftekhariDavid Sinton
Oct 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Si Hoon LeeChristy L Haynes
Oct 26, 2013·Nanophotonics·Andreas B DahlinSang-Hyun Oh

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