Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.

ChemMedChem
Kyle J SommersKevin P C Minbiole

Abstract

Inspired by the incorporation of metallocene functionalities into a variety of bioactive structures, particularly antimicrobial peptides, we endeavored to broaden the structural variety of quaternary ammonium compounds (QACs) by the incorporation of the ferrocene moiety. Accordingly, 23 ferrocene-containing mono- and bisQACs were prepared in high yields and tested for activity against a variety of bacteria, including Gram-negative strains and a panel of clinically isolated MRSA strains. Ferrocene QACs were shown to be effective antiseptics with some displaying single-digit micromolar activity against all bacteria tested, demonstrating yet another step in the expansion of structural variety of antiseptic QACs.

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Citations

Jul 19, 2021·European Journal of Medicinal Chemistry·Jing LiangLixia Chen

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