Metallodrugs are unique: opportunities and challenges of discovery and development.

Chemical Science
Elizabeth J AnthonyZijin Zhang

Abstract

Metals play vital roles in nutrients and medicines and provide chemical functionalities that are not accessible to purely organic compounds. At least 10 metals are essential for human life and about 46 other non-essential metals (including radionuclides) are also used in drug therapies and diagnostic agents. These include platinum drugs (in 50% of cancer chemotherapies), lithium (bipolar disorders), silver (antimicrobials), and bismuth (broad-spectrum antibiotics). While the quest for novel and better drugs is now as urgent as ever, drug discovery and development pipelines established for organic drugs and based on target identification and high-throughput screening of compound libraries are less effective when applied to metallodrugs. Metallodrugs are often prodrugs which undergo activation by ligand substitution or redox reactions, and are multi-targeting, all of which need to be considered when establishing structure-activity relationships. We focus on early-stage in vitro drug discovery, highlighting the challenges of evaluating anticancer, antimicrobial and antiviral metallo-pharmacophores in cultured cells, and identifying their targets. We highlight advances in the application of metal-specific techniques that can assist...Continue Reading

References

Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J A O'HaraJ F Vollano
Aug 17, 1996·Mutation Research·B J SandersonW A Denny
Mar 28, 1998·Antimicrobial Agents and Chemotherapy·O DomarleP Millet
Oct 15, 1998·Cancer Chemotherapy and Pharmacology·G LümmenH Rübben
Apr 5, 2001·Journal of Virology·J A SchwartzS J Silverstein
Jan 2, 2003·The Journal of Biological Chemistry·Aleksandra MandicMaria C Shoshan
May 29, 2004·Trends in Pharmacological Sciences·Anthony J TurnerNigel M Hooper
Aug 11, 2004·Ultrasonics Sonochemistry·Ionel RosenthalPeter Riesz
Dec 30, 2004·Angewandte Chemie·Nicholas C LloydRon S Ronimus
Dec 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fuyi WangPeter J Sadler
Feb 2, 2006·Journal of the American Chemical Society·Anna F A PeacockPeter J Sadler
Apr 25, 2006·Journal of Structural Biology·Matthew D HallTrevor W Hambley
Jul 21, 2006·The Journal of Physical Chemistry. B·Esben SkovsenPeter R Ogilby
Mar 30, 2007·Fundamental & Clinical Pharmacology·Sara William-FaltaosGérard Bastian
Apr 5, 2007·Nature Protocols·Nicolaas A P FrankenChris van Bree
Jun 15, 2007·Toxicologic Pathology·Susan Elmore
Jul 25, 2007·Angewandte Chemie·Nan YangJian-Dong Huang
Nov 14, 2007·Journal of Medicinal Chemistry·Wolfgang F SchmidBernhard K Keppler
Jul 4, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Soumya ChatterjeePaul J Dyson
Aug 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sarah J DouganPeter J Sadler
Oct 11, 2008·Cell Death and Differentiation·G KroemerUNKNOWN Nomenclature Committee on Cell Death 2009
Oct 14, 2008·Channels·Birgit T PriestMaria L Garcia
Nov 21, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Faustine DubarChristophe Biot
Feb 20, 2009·Chemical Communications : Chem Comm·Eric Meggers
Jul 2, 2009·Surgical Infections·J Wesley Alexander
Sep 24, 2009·Chemical Reviews·Reagan McRaeChristoph J Fahrni
Oct 8, 2009·Analytica Chimica Acta·Shailini AshokaMalcolm R Reid
Nov 17, 2009·Journal of Chemical Biology·Anne E WestonLucy M Collinson
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Francis LéviJean Clairambault

❮ Previous
Next ❯

Citations

May 19, 2021·Chembiochem : a European Journal of Chemical Biology·Johannes Karges, Seth M Cohen
Jun 19, 2021·Journal of Computer-aided Molecular Design·José L Medina-FrancoBárbara I Díaz-Eufracio
Jul 3, 2021·Pharmaceutics·Alexandra-Cristina Munteanu, Valentina Uivarosi
May 20, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Lukáš MasarykPavel Štarha
Jun 3, 2021·Biomedicines·Damiano CirriTiziano Marzo
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·João Franco MachadoTânia S Morais
Feb 23, 2021·Drug Delivery and Translational Research·Pedro FarinhaM Manuela Gaspar
Apr 8, 2021·Journal of Inorganic Biochemistry·Prinessa ChellanPeter J Sadler
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alessandra BarbanenteNicola Margiotta
May 22, 2021·ChemMedChem·Angelo FreiMark A T Blaskovich
Jul 17, 2021·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Snežana Jovanović-StevićBiljana Petrović
Jul 27, 2021·Frontiers in Chemistry·Lynn S LisboaJames D Crowley
Jul 25, 2021·International Journal of Molecular Sciences·Alice De PaloFabio Marchetti
Aug 7, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Mert Olgun Karataşİsmail Özdemir
Aug 18, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Andreia ValentePetra Heffeter
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sherin AbdelrahmanJoanna Izabela Lachowicz
Aug 29, 2021·Pharmaceutics·Simona BracciniFabio Marchetti
Aug 31, 2021·RSC Chemical Biology·Przemysław BiegańskiKonrad Kowalski
Sep 18, 2021·Chemical Society Reviews·Darren M GriffithHongzhe Sun
Sep 4, 2021·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Nicholas J TerrillWim Bras
Sep 29, 2021·Journal of the American Chemical Society·Daniel SzczerbaSimon A J Kimber
Sep 24, 2021·Chemistry : a European Journal·Monika CziferszkyRonald Gust
Oct 26, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Danielle van der WesthuizenOrde Q Munro
Nov 12, 2021·Journal of Medicinal Chemistry·Robin RamosJoëlle Sobczak-Thépot
Nov 13, 2021·Inorganic Chemistry·Rajeeva Lochana PanchangamKaushik Chanda
Sep 9, 2021·Recent Patents on Anti-cancer Drug Discovery·Eirini FotopoulouLuca Ronconi

❮ Previous
Next ❯

Methods Mentioned

BETA
surface plasmon resonance
X-ray
flow cytometry
enzyme-linked immunosorbent assays
Assay
Fluorescence-activated Cell Sorting
pull-down
glycosylation
thermal-shift
chemical treatment

Clinical Trials Mentioned

NCT03945162
NCT00005067
NCT04240639
NCT02688101
NCT01139346
NCT01415297
NCT03258320
NCT01259479
NCT03771820
NCT00910741

Software Mentioned

XANES
Cryo
XRT
COMPARE

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

CRISPRi Screens for Antibiotics

The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Current Topics in Medicinal Chemistry
Seiji Komeda, Angela Casini
© 2021 Meta ULC. All rights reserved