Metalloprotein tunnel junctions: compressional modulation of barrier height and transport mechanism

Faraday Discussions
J J DavisJianwei Zhao

Abstract

Though the incorporation of sensory or potentially-switchable biological entities into electronic devices brings with it a number of complicating issues associated with hydration, structural complexity/delicacy, and low conductance, the possibility of resolving properties of fundamental importance (such as the influence of protein fold on conductance) at a molecularly-resolved level, are exciting. Our ability to analyse charge transport through a biological macromolecule remains, though, a significant practical and theoretical challenge. Though much information can be gained by carrying out such examinations at a molecular level, there exist few methods where such controlled analyses are, in fact, feasible. Here we report on the electron transport characteristics of a blue copper metalloprotein as characterized by conductive-probe atomic force microscopy. At very low imposed force, contact resistance is high, electrical contact unstable, and the junction undergoes dielectric breakdown at 1.1-1.5 GV m(-1). At increased applied force, the current-voltage characteristics are entirely reproducible and well-described by a Simmons (non-resonant) tunnelling model. Though highly resistive, observations demonstrate the ability of the pr...Continue Reading

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Citations

Nov 30, 2012·Journal of the American Chemical Society·Juan M ArtésPau Gorostiza
Feb 23, 2013·Journal of the American Chemical Society·John E JettPeter M Gannett
May 5, 2009·Journal of the American Chemical Society·Sara A DiBenedettoTobin J Marks
Mar 10, 2010·Journal of the American Chemical Society·Izhar RonDavid Cahen
Dec 26, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nadav AmdurskyDavid Cahen
Sep 27, 2006·Physical Chemistry Chemical Physics : PCCP·Andrea AlessandriniPaolo Facci
May 4, 2007·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Gujin J SuThomas Wandlowski
Mar 29, 2012·Chemistry : a European Journal·Amol V PatilJason J Davis
Feb 18, 2017·Physical Chemistry Chemical Physics : PCCP·Xiaoyue ZhangYue Zheng
Jan 6, 2018·Reports on Progress in Physics·Christopher D BostickDavid Lederman
Mar 26, 2015·Nanotechnology·Christopher D BostickDavid Lederman
Sep 17, 2008·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Jason J DavisWang Xi
Jul 20, 2017·Small·Montserrat López-MartínezPau Gorostiza
Jul 14, 2007·The Journal of Physical Chemistry. B·Daniel AxfordBen Peters
Mar 25, 2010·Accounts of Chemical Research·Izhar RonDavid Cahen
Nov 26, 2010·Nano Letters·Eduardo Antonio Della PiaMartin Elliott
Oct 18, 2007·The Journal of Physical Chemistry. B·Nicholas S WiggintonMichael F Hochella

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