Metallostar Assemblies Based on Dithiocarbamates for Use as MRI Contrast Agents.

Inorganic Chemistry
Hannah L PerryJames D E T Wilton-Ely

Abstract

Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d-f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM-1 s-1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM-1 s-1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM-1 s-1 per gadolinium unit being observed for the trigadolinium d-f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d-f hybrids with potential for use as high-performance MRI contrast agents.

References

Nov 29, 2005·Chemistry : a European Journal·João Bruno LivramentoEva Tóth
May 27, 2006·Chemical Society Reviews·Melanie BottrillNicholas J Long
Jun 14, 2006·Chemistry : a European Journal·Jérôme CostaAndré E Merbach
Jun 27, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Ming-Hung OuYun-Ming Wang
Feb 20, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·João Bruno LivramentoEva Tóth
Jun 4, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Petr HermannIvan Lukes
Sep 25, 2008·Inorganic Chemistry·James D E T Wilton-ElyGraeme Hogarth
Mar 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Loïck MoriggiLothar Helm
Apr 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Edward R KnightJames D E T Wilton-Ely
Aug 8, 2009·Chemical Communications : Chem Comm·Marco MarradiSoledad Penadés
Sep 3, 2009·Journal of the American Chemical Society·Loïck MoriggiLothar Helm
Sep 23, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Yvonne H LinJames D E T Wilton-Ely
Dec 22, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Daniel T SchühleJoop A Peters
Mar 11, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Katie OliverJames D E T Wilton-Ely
Apr 1, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Pascal MiévilleLothar Helm
Sep 15, 2011·Inorganic Chemistry·Geert DehaenTatjana N Parac-Vogt
Dec 6, 2011·Chemistry : a European Journal·Geert DehaenTatjana N Parac-Vogt
Jul 26, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Elke DebroyeTatjana N Parac-Vogt
Jul 31, 2012·Inorganic Chemistry·Geert DehaenTatjana N Parac-Vogt
Oct 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhuxian Zhou, Zheng-Rong Lu
Dec 7, 2013·Inorganic Chemistry·Charlotte RivasNicholas J Long
Sep 12, 2014·Chemical Society Reviews·Elke Debroye, Tatjana N Parac-Vogt
Jan 16, 2015·Chemical Society Reviews·Angelo J Amoroso, Simon J A Pope
Mar 5, 2015·Chemistry : a European Journal·Graeme J StasiukNicholas J Long
Jun 18, 2015·Journal of the American Chemical Society·Victoria S R HarrisonThomas J Meade
Nov 23, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Anita ToscaniJames D E T Wilton-Ely
Sep 18, 2018·Accounts of Chemical Research·Thomas Just Sørensen, Stephen Faulkner
Apr 11, 2019·Chembiochem : a European Journal of Chemical Biology·Océane FlorèsEwen Bodio
May 28, 2019·Chemistry : a European Journal·Nicolas G ChablozJames D E T Wilton-Ely
Oct 9, 2019·Journal of the American Chemical Society·Hao Li, Thomas J Meade

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved