Metallothionein - overexpression as a highly significant prognostic factor in melanoma: a prospective study on 1270 patients

British Journal of Cancer
G WeinlichB Zelger

Abstract

Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined the role of MT overexpression in melanoma patients as a prognostic factor for progression and survival. Between 1993 and 2004, 3386 patients with primary cutaneous melanoma were investigated by using a monoclonal antibody against MT on routinely fixed, paraffin-embedded tissues. In all, 1270 patients could be followed up for further statistical analysis (Fisher's exact test, Mantel-Haenszel chi2 test, Kaplan-Meier curves). The MT data of disease-free interval and overall survival were compared univariately and multivariately in Cox regression analysis. Immunohistochemical overexpression of MT in tumour cells of patients with primary melanoma (310 of 1270; 24.4%) was associated with a higher risk for progression (117 of 167; 70.1%) and reduced survival (80 of 110; 72.7%) of the disease (P<0.0001). Similarly, Kaplan-Meier curves gave highly significant disadvantages for the MT-positive group. Univariate analysis (relat...Continue Reading

References

Jan 1, 1991·Methods in Enzymology·B Jasani, M E Elmes
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J J Schroeder, R J Cousins
Jan 1, 1988·Critical Reviews in Food Science and Nutrition·R NathM Sharma
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M KarasawaT Kuroki
Oct 1, 1985·Molecular and Cellular Biology·M KarinG Wong
Jan 1, 1994·Virchows Archiv : an International Journal of Pathology·D OfnerK W Schmid
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·G OhshioM Imamura
Nov 14, 1997·Histopathology·B Jasani, K W Schmid
May 20, 1998·Biochemical and Biophysical Research Communications·Y OkazakiA Naganuma
Oct 8, 1998·Histopathology·V K ShuklaA Gautam
Jan 29, 2000·The Journal of Investigative Dermatology·N NishimuraC Tohyama
Apr 8, 2000·Critical Reviews in Biochemistry and Molecular Biology·A T MilesV Rodilla
Feb 15, 2001·The American Journal of Dermatopathology·K SugitaM Asahi
Dec 4, 2003·Mutation Research·M George CherianBoon-Huat Bay
Jun 10, 2004·Pathology Oncology Research : POR·Rongxian JinBoon-Huat Bay
Jul 29, 2004·Histopathology·S E TheocharisG P Kouraklis
Jan 19, 2005·World Journal of Surgical Oncology·Dionisios MitropoulosChristos Kittas
Sep 17, 2005·BMC Immunology·Xiuyun YinMichael A Lynes

❮ Previous
Next ❯

Citations

Jan 16, 2007·Archives of Dermatological Research·Jochen UtikalSelma Ugurel
Mar 26, 2009·Journal of the National Cancer Institute·Bonnie E Gould RothbergDavid L Rimm
Mar 13, 2012·Pathology Oncology Research : POR·Aleksandra ZamirskaJacek C Szepietowski
Mar 12, 2015·Molecular Medicine Reports·Shinichiro Takahashi
Feb 14, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Peeter Karihtala, Ylermi Soini
Feb 24, 2015·Cancer Chemotherapy and Pharmacology·Blanka TaribaAlica Pizent
Jul 9, 2014·International Journal of Molecular Sciences·Gudrun RatzingerHeidelinde Fiegl
Jun 8, 2013·International Journal of Molecular Sciences·Jarmila KruseovaTomas Eckschlager
Feb 8, 2018·Molecular Diagnosis & Therapy·Anna EisensteinRhoda M Alani
Dec 25, 2008·Nature Clinical Practice. Oncology·Allison R LarsonRhoda M Alani
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Heather M McGeeRoger S Chung
May 4, 2010·Annals of Indian Academy of Neurology·Amit Ray, Susan M Bowyer
Jan 15, 2014·PloS One·Jaromir GumulecMichal Masarik
Feb 4, 2014·Virchows Archiv : an International Journal of Pathology·Mario Mandalà, Daniela Massi
May 8, 2014·The American Journal of Dermatopathology·Ossama AbbasJag Bhawan
Jul 27, 2006·Blood·Christian Bjørn PoulsenElisabeth Ralfkiaer
Jan 1, 2014·Healthcare·Stamatina VerykiouPenny E Lovat
Aug 25, 2018·Journal of Hematology & Oncology·Manfei Si, Jinghe Lang
Mar 6, 2019·Current Topics in Medicinal Chemistry·Vadim V Tarasov TarasovGjumrakch Aliev
Sep 2, 2011·Histopathology·David A MooreGerald S Saldanha
Jun 27, 2009·Cancer Control : Journal of the Moffitt Cancer Center·Selma UgurelJürgen C Becker
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Frank L Meyskens, Marianne Berwick
Feb 28, 2021·Environmental Science and Pollution Research International·Samia M M MohafrashAbdel-Tawab H Mossa
Sep 22, 2020·Pathology, Research and Practice·Qichen LiuZhong Chen

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BETA
biopsy

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SPSS

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