PMID: 6413769Jan 1, 1983Paper

Metallothionein--aspects related to copper and zinc metabolism

Journal of Inherited Metabolic Disease
R J Cousins

Abstract

Metallothionein is a cysteine-rich, low molecular weight protein that binds zinc, copper and cadmium. It is inducible in liver, kidney and intestine by glucocorticoids, changes in the dietary zinc supply, acute administration of various metals, food restriction, infection, stress and endotoxin treatment. Regulation of synthesis involves altered gene expression. The protein is fairly rapidly degraded when zinc is the primary metal species bound, but the degradation rate is diminished when cadmium or copper are bound as well. The net result of metallothionein production seems to be accumulation of bound metal and/or intracellular metal redistribution. The accumulation of copper in various tissues of individuals with Menkes' and Wilson's diseases may be related to altered metallothionein turnover. The physiological function is not clear, but the response of metallothionein to hormonal stimuli is suggestive of an important role in cellular metabolism.

References

Apr 12, 1975·Lancet·T LombeckH J Bremer
Feb 1, 1978·Biochimica Et Biophysica Acta·M L Failla, R J Cousins
Sep 1, 1975·Archives of Biochemistry and Biophysics·D R WingeK V Rajagopalan
Apr 15, 1977·The Biochemical Journal·K S SquibbS L Feldman
Aug 22, 1977·Biochemical and Biophysical Research Communications·G Madapallimatam, J R Riordan
Feb 19, 1979·Biochimica Et Biophysica Acta·M L FaillaM J Mascenik
Aug 1, 1979·Journal of Inorganic Biochemistry·A C HallI Bremner
Aug 28, 1979·Biochemical and Biophysical Research Communications·K R EtzelR J Cousins
Jun 1, 1978·Pediatric Research·N G BeratisK Hirschhorn
Dec 18, 1978·Biochimica Et Biophysica Acta·S L FeldmanR J Cousins
Sep 1, 1978·Journal of Toxicology and Environmental Health·S L FeldmanR J Cousins
Jun 1, 1976·The Biochemical Journal·I Bremner, B W Young
Jul 1, 1976·The British Journal of Nutrition·I Bremner, N T Davies
Aug 1, 1976·The Biochemical Journal·I Bremner, B W Young
Oct 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·M P Richards, R J Cousins
Dec 15, 1976·The Biochemical Journal·S L Feldman, R J Cousins
Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·T J GokaR R Howell
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·Y KojimaJ H Kägi
May 1, 1975·The New England Journal of Medicine·A Jacobs, M Worwood
Jun 16, 1975·Biochemical and Biophysical Research Communications·M P Richards, R J Cousins
May 20, 1972·Lancet·D M DanksB Turner
Oct 15, 1972·Biochemical Pharmacology·M Webb
Feb 15, 1974·FEBS Letters·R H Bühler, J H Kägi
Aug 1, 1981·The Journal of Nutrition·M P MenardR J Cousins
Jul 1, 1982·Developmental Biology·A J Ouellette
Dec 1, 1982·The Journal of Nutrition·K R EtzelR J Cousins
Jun 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·K R Etzel, R J Cousins
Jul 1, 1982·The New England Journal of Medicine·J C Chang, Y W Kan
May 1, 1980·The Biochemical Journal·A O Udom, F O Brady
Nov 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T Y LiD H Petering
Jul 1, 1981·The British Journal of Nutrition·M J JacksonR H Edwards
Oct 1, 1981·Bioscience Reports·J F MercerD M Danks
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J D Otvos, I M Armitage
Jul 1, 1980·The Journal of Nutrition·B C StarcherJ G Madaras
Jan 15, 1982·Biochemical Pharmacology·M Webb, K Cain
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K G DanielsonP C Huang
Apr 1, 1982·The Journal of Nutrition·M R Swerdel, R J Cousins
Jan 1, 1982·Methods in Enzymology·J S GarveyC C Chang
Mar 1, 1981·Pediatric Research·G U LabadieN G Beratis
Jul 16, 1981·Nature·N GlanvilleR D Palmiter

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Citations

Jan 1, 1992·Biological Trace Element Research·P Allain, G Leblondel
Jun 1, 1988·Biological Trace Element Research·G LeBlondel, P Allain
Jun 17, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Scott H GarrettDonald A Sens
Nov 1, 2007·European Biophysics Journal : EBJ·J Pablo Huidobro-ToroClaudio Coddou
Sep 12, 2006·Cell Biology and Toxicology·R BrandãoC W Nogueira
Nov 1, 2013·The Journal of Nutrition·Denis M Medeiros
Jun 10, 2017·International Journal of Molecular Sciences·Artur Krężel, Wolfgang Maret
Nov 22, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Nov 13, 2019·Reviews in the Neurosciences·Thomas BerryAhmed A Moustafa
Jan 1, 1983·Journal of Inherited Metabolic Disease·P J Aggett, N T Davies
Jan 1, 1983·Journal of Inherited Metabolic Disease·S H Laurie
Sep 1, 1986·Biological Trace Element Research·J SeagraveH A O'Brien
Jan 1, 1983·Journal of Inherited Metabolic Disease·G S Fell
Dec 1, 1985·Biological Trace Element Research·P ButzenB Starcher
Jul 11, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Tanja BaeckerAndreas M Grabrucker
Jul 1, 1989·Biological Trace Element Research·C D Klaassen, L D Lehman-McKeeman
Mar 10, 2016·Anais Da Academia Brasileira De Ciências·Suellen C M SalesMarcela M Ribeiro
Feb 19, 2002·Kidney International·Doyeob KimDonald A Sens
Dec 1, 1986·Toxicology·H E HeilmaierK H Summer
Jan 1, 1988·Toxicology and Applied Pharmacology·L D Lehman-McKeemanC D Klaassen
Jan 1, 1988·Toxicology and Applied Pharmacology·L D Lehman-McKeemanC D Klaassen

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