Metallothionein and cortisol receptor expression in gills of Atlantic salmon, Salmo salar, exposed to dietary cadmium

Aquatic Toxicology
Z C DangR A Lock

Abstract

Commercial fish feeds may contain significant levels of cadmium (Cd). However, little is known about the effects of dietary cadmium on fish organs, especially gills, the key osmoregulatory organ. We therefore studied the effects of dietary cadmium on metallothionein (MT) and cortisol receptor (GR) immunoreactivity in the branchial epithelium of the Atlantic salmon (Salmo salar). Cadmium was daily administered via food at 0.2mg (control), 5mg (low dose) and 125 mg (high dose) Cd per kilogram dry pellet weight. Fish were sampled after four and eight weeks. After both four and eight weeks, plasma cadmium concentration had increased significantly only in fish fed the high cadmium dose. Plasma calcium, sodium, chloride and cortisol levels were not affected. In the controls, most MT was colocated with the chloride cell marker, Na(+)/K(+)-ATPase, but some MT was present in pavement and respiratory cells. GR expression was found in chloride, pavement, respiratory and undifferentiated cells in all fish groups, but cadmium accumulation and a marked stimulation of MT expression were seen only in the chloride cells in the gills of fish fed the high cadmium dose. Cadmium treatment did not alter GR expression. When the double staining techni...Continue Reading

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Citations

Mar 3, 2011·General and Comparative Endocrinology·M C Subhash Peter
May 26, 2004·Ecotoxicology and Environmental Safety·P Chandra, A R Khuda-Bukhsh
Jul 13, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yu-Siang LinSu Mei Wu
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Feb 8, 2011·Plant Physiology and Biochemistry : PPB·Adám SoltiFerenc Fodor
Dec 4, 2012·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joel S Klinck, Chris M Wood
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Sep 25, 2007·Ecotoxicology and Environmental Safety·Young Sun ChoYoon Kwon Nam

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