Metallothionein expression as prognostic factor for transitional cell carcinoma of bladder

Urology
Yasuto YamasakiJ I Izawa

Abstract

To determine whether metallothionein (MT) protein expression is associated with clinical outcomes in patients with transitional cell carcinoma (TCC) of the bladder. Archival pathologic radical cystectomy and transurethrally resected specimens and medical charts were reviewed for 123 patients with TCC. Patients were divided into groups based on the TNM stage, tumor grade, and MT protein expression in the primary tumor. Survival and disease progression were correlated with MT expression. The mean patient age was 66 years (range 41 to 92). Of the 123 tumors, 21, 13, 18, 24, 17, and 30 were pathologically staged as pTa, pT1, pT2, pT3, pT4, and pTis, respectively; 28, 15, 14, and 66 tumors had a histologic grade of X, 1, 2, and 3, respectively. On univariate analysis, TNM stage and tumor grade predicted survival and progression outcomes. MT expression was detected in 69 (56.9%) of 123 bladder cancer specimens. Greater MT protein expression was associated with worse overall survival, disease-specific survival, disease-free survival, and disease-free progression (P = 0.0004, P = 0.05, P = 0.0008, and P = 0.0005, respectively). MT protein expression in the primary tumor of TCC specimens appeared to be associated with overall survival, ...Continue Reading

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Citations

Jul 21, 2009·BMC Veterinary Research·André F S AmaralArmindo S Rodrigues
Apr 1, 2010·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Heather M McGeeRoger S Chung
Jan 22, 2013·Acta histochemica·Alessandra de Castro Miranda VianaMaria Cássia Ferreira Aguiar
Apr 8, 2009·Progress in Histochemistry and Cytochemistry·Mie Ø PedersenMilena Penkowa
May 15, 2013·Journal of Gastroenterology and Hepatology·Yangsoon Park, Eunsil Yu
Jan 15, 2014·PloS One·Jaromir GumulecMichal Masarik
Aug 25, 2018·Journal of Hematology & Oncology·Manfei Si, Jinghe Lang
Mar 20, 2019·International Journal of Molecular Sciences·Rhiannon V McNeillJennifer Southgate
Mar 1, 2019·International Journal of Molecular Sciences·Ke-Hung TsuiHorng-Heng Juang

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