PMID: 11342961May 9, 2001Paper

Metallothionein expression in renal cell carcinoma: subcellular localization and prognostic significance

The Journal of Urology
E TüzelM Sade

Abstract

We investigated the immunohistochemical localization of metallothionein (MT) in renal cell carcinoma and determined the potential role of MT expression as a possible prognostic variable for tumor proliferation and progression. Tumor tissue blocks from 70 patients with renal cell carcinoma who underwent radical or partial nephrectomy were investigated. Mean followup plus or minus standard error was 36 +/- 3 months. Immunohistochemical testing was performed by the avidin-streptavidin method using a monoclonal mouse antiMT antibody. MT staining intensity in samples was evaluated semiquantitatively. The subcellular distribution of MT was also determined. Staining characteristics were compared with the clinicopathological results. MT immunostaining was found in 39 of 70 tumors (55.7%) and subcellulary MT was localized in the cytoplasm, nucleus and cell membrane. The survival of patients with MT immunostaining was significantly worse than that of those with MT negative results (p = 0.02). A significant relationship of higher tumor grade and MT staining intensity was observed in grades I and III (p = 0.01), and grades II and III (p = 0.02) tumors. No association was found of MT expression and pathological stage. Sarcomatoid tumors sho...Continue Reading

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Citations

May 1, 2002·Current Opinion in Oncology·Paul Godley, Steven W Kim
Jan 19, 2005·World Journal of Surgical Oncology·Dionisios MitropoulosChristos Kittas
Jan 1, 2013·Thyroid Research·Bartosz PulaPiotr Dziegiel
Mar 4, 2005·Journal of the American Society of Nephrology : JASN·Won K HanJoseph V Bonventre
Aug 7, 2014·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Deeksha PalRajendra Prasad
Mar 1, 2016·Journal of Alzheimer's Disease : JAD·Pavlína AdamVojtěch Adam
May 15, 2013·Journal of Gastroenterology and Hepatology·Yangsoon Park, Eunsil Yu
Jul 13, 2014·Pathology Oncology Research : POR·Bartosz PulaMarzena Podhorska-Okolow

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