PMID: 8452482Jan 1, 1993Paper

Metallothionein in isolated pancreatic islets of mice: induction by zinc and streptozotocin, a naturally occurring diabetogen

Archives of Toxicology
S ZimnyH Gleichmann

Abstract

Metallothionein (MT) concentrations were determined in the cytosol of isolated pancreatic islets of mice, using both the cadmium (Cd)-heme and the Cd-Chelex assay. Both constitutive MT levels and significant MT induction were detected in islet cells. For MT induction, mice were injected intraperitoneally (i.p.) with either zinc sulfate (Zn) or the diabetogen streptozotocin (STZ). Following an i.p. injection of 15 mg Zn.kg-1 body weight (body wt), the mean index of MT induction found in islets was comparable to that found in liver tissue, which was used as control. After i.p. injection of 30 mg Zn.kg-1 or a single high dose of STZ (100 or 200 mg.kg-1), the indices of MT induction in islets exceeded those in liver by a factor of 1.3, 2.5, or 1.5. After multiple low doses of STZ (3 or 5 x 40 mg.kg-1 given on consecutive days), in contrast, the MT induction indices in islets exceeded those in liver by a factor of 3.5 and 3.9 for 3 x 40 respectively 5 x 40 mg STZ.kg-1. In conclusion, our results demonstrate constitutive MT levels in isolated pancreatic islets and significant MT induction after i.p. injection with Zn or STZ, in particular after repeated low doses of STZ.

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Citations

Jul 26, 2002·Life Sciences·Sabine Schulte im WaldeHelga Gleichmann
Feb 24, 2000·Toxicology·M J Solis-HerediaA Albores
Aug 15, 2000·Molecular and Cellular Endocrinology·S G LaychockC O Simpkins
Dec 7, 2007·BioFactors·Md Shahidul Islam, Du Toit Loots
Sep 19, 2015·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Priyanga RanasingheGodwin R Constantine
Apr 1, 2004·Nonlinearity in Biology, Toxicology, Medicine·Lu Cai
Oct 31, 2002·Pharmacology & Toxicology·Lars GilleHelga Gleichmann
Apr 29, 1998·Journal of the American College of Nutrition·A B Chausmer
Apr 21, 2004·Experimental Biology and Medicine·Abdelhakim LgssiarHelga Gleichmann
Aug 23, 2019·Physiological Reviews·David S Wishart
Jan 1, 1997·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P RösenH Gleichmann
Aug 15, 2001·American Journal of Physiology. Cell Physiology·M D ApostolovaM G Cherian

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