PMID: 2484582Jul 1, 1989Paper

Metallothionein induction by nonsteroidal antiinflammatory drugs

Biological Trace Element Research
K H SummerJ Abel

Abstract

In the present study we report on the effects of commonly used nonsteroidal antiinflammatory drugs on metallothionein (MT) and MT-I mRNA levels. A single dose of chloroquine (100 mg/kg), diclofenac (100 mg/kg), indomethacin (10 mg/kg), or piroxicam (100 mg/kg) was administered ip to C57B1 mice. After 18 h, MT levels were determined with a Cd-saturation radioassay. MT-I mRNA levels were measured by Northern Blot analyses using a probe containing the mouse MT-I gene. All drugs tested caused an increase in the MT content of the liver but not of the kidneys and lung. The lowest and highest effects were observed with chloroquine (8 times the control value) and diclofenac (18 times), respectively. In accordance with the stimulation of MT synthesis, increased accumulation of hepatic MT-I mRNA could be demonstrated. These results indicate that elevated MT levels may contribute to the effectiveness of nonsteroidal antiinflammatory drugs in the treatment of rheumatoid arthritis (RA).

References

Jul 11, 1987·Lancet·I H ScheinbergR J Stockert
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·E MuntheE Jellum
Dec 1, 1986·Toxicology·H E HeilmaierK H Summer
Jun 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·R J Cousins, M R Swerdel
Oct 1, 1985·Molecular and Cellular Biology·M KarinG Wong
Jan 1, 1986·Annals of the Rheumatic Diseases·J F KosterA J Swaak

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Citations

Jan 1, 1991·Toxicology·M Kaji, H Mikawa
Dec 4, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haim Tapiero, Kenneth D Tew
Sep 12, 2003·Current Rheumatology Reports·Frank A Wollheim
Jul 25, 2006·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R D EscalanteS B Garcia

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