PMID: 8597881Nov 1, 1995Paper

Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-11 and leukaemia inhibitory factor

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
P CoyleA M Rofe

Abstract

Potential mediators of hepatic metallothionein (MT) synthesis in adjuvant-induced arthritis were investigated in cultured rat hepatocytes. Sera from arthritic rats (14 d post-adjuvant treatment) in the presence of Zn (50 mumol/L)+dexamethasone (Dex; 1 mumol/L) increased metallothionein (MT) accumulation by 34% above that obtained with control rat serum with Zn+Dex. Endogenous IL-6 activity in serum from arthritic rats was 93 +/- 49 U/mL and was undetectable in control rat serum. The activities of TNF, IL-1 and corticosterone concentrations were the same in control and arthritic rats. The accumulation of MT in hepatocytes in the presence of Zn (10 mumol/L)+Dex (1 mumol/L) was enhanced 29% and 49% by media from lipopolysaccharide (LPS)-stimulated peritoneal macrophage (PMM) and Kupffer cell cultures (KCM), respectively. The response with PMM and KCM was quantitatively the same as that with interleukin-6 (IL-6). Analysis of PMM and KCM showed activities of 1,000-10,000 U/mL for IL-6, 100-1000 U/mL for TNF and < 10,000 U/mL for IL-1, the latter detected only in PMM. LPS alone enhanced the accumulation of MT above Zn+Dex in a dose dependent manner. A significant LPS response was obtained at 5 mg/L with a maximal stimulation above Zn...Continue Reading

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Citations

Oct 27, 1999·Biological Trace Element Research·E BrambilaM Waalkes
Jun 5, 2003·Journal of Pediatric Surgery·Barbara E WildhaberDaniel H Teitelbaum
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·H A BabaM C Deng
Jun 16, 2001·Toxicological Sciences : an Official Journal of the Society of Toxicology·E Canpolat, M A Lynes
Apr 10, 2002·Microbiology and Immunology·Masaharu MitaSeiichiro Himeno
Apr 30, 2009·Annual Review of Nutrition·Hajo Haase, Lothar Rink
Jan 21, 2014·Environmental Toxicology and Pharmacology·Xiaokun PeiZhifeng Liu
Jul 29, 2018·European Journal of Immunology·Jinxia SunZhong Huang

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