Metallothionein induction related to hepatic structural perturbations and antioxidative defences in roach (Rutilus rutilus) exposed to the fungicide procymidone

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
S Paris-PalaciosG Vernet

Abstract

A variety of stresses, hormones, glucocorticoids and cytokines are known to induce metallothioneins (MTs) in animals. The aim of this study was to investigate the effects of chemical stress induced by the dicarboximide fungicide procymidone on hepatic structure, MT content and antioxidative defences (catalase and glutathione reductase activities and glutathione content) in the common fish Rutilus rutilus. Catalase and glutathione reductase activities remained stable throughout the experiment. Four days of exposure to 0.2 or 0.4 mg l(-1) of procymidone induced an obvious increase in liver MT content, perturbation of metal MT contents, and an increase in hepatic glutathione content. After 14 days' exposure, obvious and large structural alterations of the hepatic parenchyma occurred simultaneously with a decrease in MT and glutathione content. These events were interpreted as degeneration of the liver. Fish exposed for 14 days to procymidone and then placed for 14 days in clean water showed nearly complete decontamination of the liver, but MT concentrations remained high. The toxicological significance of these events is discussed.

References

Jan 1, 1987·Experientia. Supplementum·J H Kägi, Y Kojima
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1983·Annual Review of Biochemistry·A Meister, M E Anderson
Jan 1, 1997·Annual Review of Nutrition·R A Goyer
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·E J KellyR D Palmiter
Jan 15, 1998·Progress in Nucleic Acid Research and Molecular Biology·S L Samson, L Gedamu
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·L J JiangB L Vallee
Jul 29, 1998·Ecotoxicology and Environmental Safety·H TeisseireG Vernet
Oct 29, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·S Paris-PalaciosG Vernet
Jun 2, 2001·Ecotoxicology and Environmental Safety·A R LindeE García-Vázquez
Nov 1, 1960·Stain Technology·K C RICHARDSONE H FINKE

❮ Previous
Next ❯

Citations

Oct 9, 2008·Archives of Environmental Contamination and Toxicology·Halina I FalfushynskaSylvie Biagianti-Risbourg
Apr 15, 2009·Archives of Environmental Contamination and Toxicology·Ming-Hua Wang, Gui-Zhong Wang
Sep 4, 2009·Environmental Monitoring and Assessment·Sofiene TliliHamadi Boussetta
Dec 12, 2012·Fish Physiology and Biochemistry·Séverine Paris-PalaciosSylvie Biagianti-Risbourg
Sep 14, 2010·Ecotoxicology and Environmental Safety·Halina I FalfushynskaYoon Kwon Nam
Jul 7, 2009·Ecotoxicology and Environmental Safety·V L MariaM A Santos
Apr 10, 2009·Ecotoxicology and Environmental Safety·Halina I Falfushynska, Oksana B Stoliar
Jul 1, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Halina I FalfushinskaOksana B Stolyar
Jun 3, 2008·Ecotoxicology and Environmental Safety·Halina I Falfushynska, Oksana B Stolyar
Mar 7, 2015·Ecotoxicology and Environmental Safety·Francine F PalermoClaudia B R Martinez
Nov 29, 2011·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Halina I FalfushynskaOksana B Stoliar
Feb 4, 2019·Ecotoxicology and Environmental Safety·L JacquinS Jean

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.