Metallothionein levels in Algerian mice (Mus spretus) exposed to elemental pollution: an ecophysiological approach

Chemosphere
Carla Cristina MarquesMaria João Bebianno

Abstract

The potential use of metallothioneins (MTs) as biomarkers of trace metal contamination was evaluated for the first time in the Algerian mouse (Mus spretus). Mice were collected seasonally in an abandoned mining area (Aljustrel) and in a reference area, both located in southern Portugal. MT levels were quantified in liver and kidney by differential pulse polarography and hepatic elemental concentrations (Mn, Fe, Cu, Zn, Se) were determined by particle-induced X-ray emission. Hepatic iron and selenium concentrations were elevated in mice from Aljustrel mine when compared to reference animals. MTs levels were averagely higher in mice from Aljustrel than those originated from the reference area. A season-dependent significant effect was found on the hepatic and renal MT concentrations, characterized by higher levels in winter and lower in autumn. In contaminated mice positive relationship between liver elemental contents (Cu in autumn and Fe in winter) and MTs were found. The seasonal variation of MT suggests that probably physiological and environmental factors could influence hepatic and renal MT induction. Results seem to imply that some environmental disturbance occur in the vicinity of the Aljustrel mine. Therefore, for the ma...Continue Reading

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Citations

Oct 12, 2012·Environmental Monitoring and Assessment·Shouta M M NakayamaMayumi Ishizuka
Oct 26, 2012·Environmental Geochemistry and Health·Flavio Manoel Rodrigues da Silva JúniorAna Luíza Muccillo-Baisch
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Sep 4, 2020·Environmental Science and Pollution Research International·Krissia Aparecida de AlmeidaFlavio Manoel Rodrigues da Siva Júnior
Sep 28, 2020·Environmental Science and Pollution Research International·Varinder Singh KanwarLata Rani

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