Metallothioneins and renal ageing

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Johannes LeiererGert Mayer

Abstract

Human lifespan is increasing continuously and about one-third of the population >70 years of age suffers from chronic kidney disease. The pathophysiology of the loss of renal function with ageing is unclear. We determined age-associated gene expression changes in zero-hour biopsies of deceased donor kidneys without laboratory signs of impaired renal function, defined as a last serum creatinine >0.96 mg/dL in females and >1.18 mg/dL in males, using microarray technology and the Significance Analysis of Microarrays routine. Expression changes of selected genes were confirmed by quantitative polymerase chain reaction and in situ hybridization and immunohistochemistry for localization of respective mRNA and protein. Functional aspects were examined in vitro. Donors were classified into three age groups (<40, 40-59 and >59 years; Groups 1, 2 and 3, respectively). In Group 3 especially, genes encoding for metallothionein (MT) isoforms were more significantly expressed when compared with Group 1; localization studies revealed predominant staining in renal proximal tubular cells. RPTEC/TERT1 cells overexpressing MT2A were less susceptible towards cadmium chloride-induced cytotoxicity and hypoxia-induced apoptosis, both models for incre...Continue Reading

Associated Datasets

References

Feb 1, 1992·The Anatomical Record·J R Nyengaard, T F Bendtsen
Jan 1, 1987·Experientia. Supplementum·J H Kägi, Y Kojima
Apr 8, 1998·The American Journal of Physiology·J F ReckelhoffA K Salahudeen
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 19, 2002·Kidney International·Keshwar BaboolalWieslaw A Jurewicz
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Nov 25, 2004·PLoS Biology·Graham E J RodwellStuart K Kim
Dec 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Elissa S EpelRichard M Cawthon
Feb 2, 2006·BMC Molecular Biology·Andreas SchroederThomas Ragg
Feb 3, 2006·Journal of the American Society of Nephrology : JASN·Ann M O'HareLouise C Walter
Apr 6, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaoping YangJun Ren
Aug 17, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tetsuhiro TanakaMasaomi Nangaku
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Paul JenningsWalter Pfaller
Jun 21, 2008·Blood·Sebastian NewrzelaDorothee von Laer
Jul 18, 2008·Journal of the American Society of Nephrology : JASN·Shirong ZhengPaul N Epstein
Aug 22, 2008·American Journal of Physiology. Renal Physiology·Matthias WieserRegina Grillari-Voglauer
Jan 17, 2009·Kidney International·Ichiro KojimaMasaomi Nangaku
Apr 8, 2009·Progress in Histochemistry and Cytochemistry·Mie Ø PedersenMilena Penkowa
Jan 29, 2010·Forensic Science International : Synergy·Naoki FukudaHirotaro Iwase
Mar 2, 2011·Current Opinion in Nephrology and Hypertension·Norberto PericoAriela Benigni
Mar 3, 2011·Nature Reviews. Nephrology·Asif A Sharfuddin, Bruce A Molitoris
Mar 19, 2011·Toxicology·Klaudia Jomova, Marian Valko
May 24, 2011·World Journal of Surgical Oncology·N ThirumoorthyMalay Chatterjee
Aug 17, 2011·Free Radical Biology & Medicine·Leejin ParkYongsoo Park
Jun 14, 2012·Autophagy·Tobias B HuberZheng Dong
Oct 16, 2012·Current Pharmaceutical Design·Eugenio MocchegianiMarco Malavolta
Oct 16, 2013·Molecular Membrane Biology·Miribane Dërmaku-SopjaniMentor Sopjani
Oct 25, 2013·American Journal of Physiology. Renal Physiology·Hiromi TachibanaHirofumi Makino
Nov 30, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gert Mayer
Feb 5, 2014·Molecular & Cellular Proteomics : MCP·Aaron A MehusJohn B Shabb
Feb 20, 2014·Ageing Research Reviews·Davide BolignanoCarmine Zoccali
Mar 4, 2014·Cell Stress & Chaperones·Michael A LynesDavid A Lawrence

❮ Previous
Next ❯

Citations

Apr 29, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yuta HattoriKenji Wakai
Sep 9, 2016·International Journal of Molecular Sciences·Xue-Bin LingJi-Ke Li
Mar 18, 2017·BMC Nephrology·Moritz SchanzMartin Kimmel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

© 2022 Meta ULC. All rights reserved