Metals and molecular carcinogenesis.

Carcinogenesis
Yusha Zhu, Max Costa

Abstract

Many metals are essential for living organisms, but at higher doses they may be toxic and carcinogenic. Metal exposure occurs mainly in occupational settings and environmental contaminations in drinking water, air pollution and foods, which can result in serious health problems such as cancer. Arsenic (As), beryllium (Be), cadmium (Cd), chromium (Cr) and nickel (Ni) are classified as Group 1 carcinogens by the International Agency for Research on Cancer. This review provides a comprehensive summary of current concepts of the molecular mechanisms of metal-induced carcinogenesis and focusing on a variety of pathways, including genotoxicity, mutagenesis, oxidative stress, epigenetic modifications such as DNA methylation, histone post-translational modification and alteration in microRNA regulation, competition with essential metal ions and cancer-related signaling pathways. This review takes a broader perspective and aims to assist in guiding future research with respect to the prevention and therapy of metal exposure in human diseases including cancer.

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Citations

Sep 26, 2020·Biomolecules·Nirmal K RoyMax Costa
Apr 3, 2021·Seminars in Cancer Biology·Uttara SaranChendil Damodaran
Apr 9, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Bin WuXingming Cai
Apr 7, 2021·Seminars in Cancer Biology·Po-Shun WangChengfeng Yang
Jun 18, 2021·Seminars in Cancer Biology·Peter W HalcrowJoyce E Ohm
Jun 30, 2021·Journal of Occupational and Environmental Medicine·Feizai HaTiancheng Wang
Jul 8, 2021·Journal of Hazardous Materials·Muneeb U RehmanParvaiz Ahmad

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