Metanephric adenoma of the kidney: an electron microscopic and immunohistochemical study with quantitative DNA measurement by image analysis

Ultrastructural Pathology
A NonomuraM Ohkawa

Abstract

Metanephric adenoma of the kidney is a newly recognized entity of renal adenoma, and the electron microscopic and immunohistochemical features of the tumor have not yet been well elucidated. The authors experienced a typical case of renal metanephric adenoma and studied the electron microscopic and immunohistochemical features of the tumor together with the DNA content of the tumor cells. Electron microscopically, the tumor was composed of immature epithelial cells with relatively uniform size, poor nuclear polarity, and scant cytoplasmic organelles arranged in small tubular or rosette pattern. Immunohistochemically, the cytoplasm of the majority of the tumor cells was positive for S-100, and occasionally for alpha-1-antitrypsin and vimentin. The tumor cells were also positive for cytokeratin, lysozyme, and Leu 7, with predominantly cell membrane staining. Only tumor cells arranged in papillary or large tubular pattern were positive for epithelial membrane antigen (EMA). Tumor cells were negative for Leu M1 and HMB-45. These immunohistochemical characteristics are quite similar to those of S-shaped body of the fetal kidney. An analysis of the nuclear DNA of the tumor cells by image cytometry revealed that the tumor entirely con...Continue Reading

References

May 1, 1992·Ultrastructural Pathology·A NonomuraF Matsubara
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y NagashimaK Misugi
Jun 1, 1989·Human Pathology·G AuerO Ahrens
Feb 1, 1995·Pathology International·A NonomuraM Kadoya
Aug 15, 1987·Applied Optics·J W Bacus, L J Grace

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Citations

Mar 9, 2000·Pathology, Research and Practice·L DanielJ F Pellissier
Oct 29, 2015·Medical Molecular Morphology·Masayuki Shintaku, Kenichiro Maeno
Jul 16, 2008·Pathology, Research and Practice·Gissou AzabdaftariJohn C Cheville
Jul 21, 2001·Biophysical Journal·F BlyakhmanG H Pollack
Nov 26, 1999·Scandinavian Journal of Urology and Nephrology·H BirgissonJ G Jónasson
May 11, 1999·Archives of Pathology & Laboratory Medicine·M R PinsA A Renshaw

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