Metanephrine neuroendocrine tumor marker detection by SERS using Au nanoparticle/Au film sandwich architecture

Biomedical Microdevices
Sanda BocaSimion Astilean

Abstract

Neuroendocrine tumors, such as pheochromocytoma or paraganglioma, are dangerous tumors that constitute a potential threat for a large number of patients. Currently, the biochemical diagnosis of neuroendocrine tumors is based on measurement of the direct secretory products of the adrenomedullary-sympathetic system or of their metabolites, such as catecholamines or their metanephrine derivatives, from plasma or urine. The techniques used for analysis of plasma free metanephrines, i.e. high-performance liquid chromatography or high-performance liquid chromatography coupled with mass-spectrometry are technically-demanding and time consuming, which limit their availability. Here we demonstrate a simple, fast and low-cost method for detecting metanephrine by Surface Enhanced Raman Scattering (SERS). The protocol consists in using evaporation-induced self-assembly of gold (Au) nanoparticles incubated with the analyte, on planar gold films. The assembly process produces regions with a dense distribution of both inter-particle gaps and particle-film gaps. Finite-difference time-domain simulations confirm that both kinds of gaps are locations of enhanced electromagnetic fields resulting from inter-particle and particle-film plasmonic cou...Continue Reading

References

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Citations

May 28, 2019·Analytical and Bioanalytical Chemistry·Olga GuselnikovaOleksiy Lyutakov
Feb 6, 2018·Reviews in Analytical Chemistry·Anh H NguyenZachary D Schultz

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