PMID: 8588314May 1, 1995Paper

Metaphyseal bone lesions in young dogs with systemic canine distemper virus infection

Veterinary Microbiology
W BaumgärtnerK Gaedke

Abstract

Bone lesions, restricted to the metaphyses of long bones, were observed in young dogs with systemic distemper following experimental and spontaneous infection. Canine distemper virus (CDV) antigen was found immunocytochemically in hematopoietic marrow cells, osteoclasts, osteoblasts and rarely in osteocytes. In experimentally infected dogs, viral antigen was demonstrated in the metaphysis between 5 and 36 days after infection. Associated lesions, characterized by necrosis of osteoclasts, persistence of primary spongiosa and atrophy and necrosis of osteoblasts and marrow cells, were mild and most prominent between 8 and 32 days postinfection. Metaphyseal osteosclerosis (MO) of the long bones, varying from mild to severe, was observed macroscopically in 8 (19%) out of 42 dogs with spontaneous distemper. Affected animals were between 3 and 6 months of age and belonged mainly to the large breeds. In these animals, MO was characterized histologically by persistence of primary spongiosa, loss of bone marrow cells and necrosis of osteoclasts and bone marrow cells varying from mild to severe. Summarized, CDV-associated bone lesions were only transient and there were no indications of viral persistence in bones of dogs experimentally in...Continue Reading

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Citations

May 18, 2010·The Veterinary Clinics of North America. Small Animal Practice·Jane E Sykes
Nov 21, 2008·Veterinary Immunology and Immunopathology·A BeinekeW Baumgärtner
Mar 29, 2014·Australian Veterinary Journal·C M GreenwellA L Dunn
Jan 16, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Leandro d'Arc MorettiHélio Langoni
May 23, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Justin M StilwellDaniel R Rissi
May 28, 2020·Journal of the American Veterinary Medical Association·Sarah A JonesRoy R Pool

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