Metaplastic breast cancer: clinical significance

American Journal of Surgery
J David BeattyMaureen Reiner

Abstract

Metaplastic breast carcinoma (MBC) is a rare poorly differentiated breast cancer characterized by coexistence of ductal carcinoma with areas of matrix producing, spindle-cell, sarcomatous, or squamous differentiation; ER/PR/HER2 negativity; and a reputation for poor outcome. The Swedish Cancer Institute prospective breast cancer database (> 6500 patients; 1990-2005) has 24 MBC cases that were compared with typical breast cancer cases matched for age, date of diagnosis, stage, and ER/PR/HER2 status. The mean metaplastic primary tumor diameter was 2.5 cm. The histological/nuclear grade was high in 21 of 24 cases. No patient had distant metastasis. ER and/or PR receptor status was negative in all cases. HER2 was negative in 10 of 11 cases tested. EGFR (HER1) was positive in 7 of 7 cases tested. All patients had sentinel and/or axillary lymph node dissection and surgical resection; 18 received chemotherapy and 22 had radiation therapy. Four patients had distant recurrences 5 to 88 months from diagnosis. Five-year survival was 83% (95% confidence interval, 66-100%). Comparison with matched typical breast cancer cases revealed no major significant difference in multidisciplinary treatment patterns, recurrence, or survival. MBC is ass...Continue Reading

References

Aug 1, 1989·Human Pathology·E S WargotzH J Norris
Jul 1, 1989·Human Pathology·E S Wargotz, H J Norris
Oct 1, 1989·Cancer·E S Wargotz, H J Norris
Dec 1, 1987·The American Journal of Surgical Pathology·H A Oberman
May 1, 1984·Cancer·M W KaufmanJ L Hoehn
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L ChristensenM Blichert-Toft
Mar 21, 1998·The American Journal of Surgical Pathology·C ChhiengP P Rosen
Nov 4, 1998·Cytopathology : Official Journal of the British Society for Clinical Cytology·M NogueiraE Mendonça
Aug 10, 1999·Journal of Surgical Oncology·T C ChaoM F Chen
Jul 28, 2001·The American Journal of Surgical Pathology·N SneigeA Ayala
Mar 8, 2002·Pathology Oncology Research : POR·A Ribeiro-SilvaS Zucoloto
Apr 18, 2002·Southern Medical Journal·Manuel CaceresRhea Gardner
Sep 19, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Helenice GobbiDavid L Page
Apr 13, 2004·Seminars in Diagnostic Pathology·Edi Brogi
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Torsten O NielsenCharles M Perou
Mar 15, 2005·American Journal of Clinical Pathology·Mehrdad NadjiAzorides R Morales
May 4, 2005·Breast Cancer Research and Treatment·P J BarnesD Rayson
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael F PressDennis J Slamon

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Citations

May 11, 2010·Archives of Gynecology and Obstetrics·Kaoutar ZnatiAfaf Amarti
Feb 3, 2011·Breast Cancer Research and Treatment·Soo Youn BaeJung-Hyun Yang
Jul 1, 2010·The Indian Journal of Surgery·B Srinivas PaiAnuradha C K Rao
Oct 2, 2013·The Indian Journal of Surgery·Rama Kumari BadyalManpreet Kaur
May 3, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Juan C RoaN Volkan Adsay
Feb 28, 2008·The American Journal of Surgical Pathology·Philip M CarpenterSharon P Wilczynski
Aug 29, 2009·Pathology International·Antonia BendicMerica G Durdov
Sep 29, 2011·Pathology International·Zaher ToumiSimon Ellenbogen
Jun 5, 2013·The Pan African Medical Journal·Samia GhanemHassan Errihani
Sep 5, 2006·International Seminars in Surgical Oncology : ISSO·Corrine WongSimon Marsh
Jun 19, 2008·World Journal of Surgical Oncology·Toshiyuki HiroseAkira Tangoku
Jan 8, 2009·Cases Journal·Kristi M EssesAdam I Riker
Nov 22, 2007·AJR. American Journal of Roentgenology·Wei Tse YangMichael Z Gilcrease
Mar 20, 2010·Journal of Clinical Medicine Research·Enver IlhanMehmet Yildirim
Aug 25, 2011·Breast Cancer : Basic and Clinical Research·Christina A MinamiHelena R Chang
Jul 11, 2012·ISRN Oncology·Dhruvil R ShahSteve R Martinez
May 31, 2014·Case Reports in Oncological Medicine·Ana Paula Molina VivasFabio Abreu Alves
Mar 15, 2014·European Journal of Medical Research·Yu KangXinyu Zheng
Apr 29, 2011·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Haruko TakuwaMasakazu Toi
Jul 26, 2014·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Catalina AcevedoJose-Luis López-Guerra
Jul 18, 2014·Diagnostic Pathology·Fadwa J AltafZuhoor K Al-Gaithy
Oct 23, 2012·The Breast : Official Journal of the European Society of Mastology·Emad A RakhaIan O Ellis
Apr 3, 2012·The Breast : Official Journal of the European Society of Mastology·Renê GerhardFernando Schmitt
Nov 22, 2007·Neoplasia : an International Journal for Oncology Research·Mirco GalièAndrea Sbarbati
Mar 20, 2010·Human Pathology·Nao OkadaTakayuki Kinoshita
Jun 9, 2009·Current Problems in Surgery·Kristin L CoxV Suzanne Klimberg
Nov 15, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·William J Irvin, Lisa A Carey
Feb 7, 2014·Experimental Hematology & Oncology·Theresa L SchwartzEddy C Hsueh
Nov 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Onur EsbahBerna Oksuzoglu
Jun 2, 2015·Archives of Pathology & Laboratory Medicine·Elizabeth McKinnon, Philip Xiao
Jun 22, 2013·The Breast : Official Journal of the European Society of Mastology·Hung-Wen LaiDar-Ren Chen
Apr 18, 2015·Journal of Clinical Imaging Science·Umar Shafique ChaudhryLaurie L Fajardo
Feb 19, 2015·Current Oncology Reports·Sausan Abouharb, Stacy Moulder
Nov 26, 2014·British Journal of Cancer·E A RakhaI O Ellis
Jul 12, 2014·Annals of Surgical Oncology·Rebecca A NelsonLily L Lai
Jul 20, 2016·Clinical Breast Cancer·Ioannis-Georgios TzanninisGeorge Fotopoulos
Mar 14, 2009·International Journal of Surgical Pathology·Katja GwinFattaneh A Tavassoli
Feb 16, 2012·International Journal of Surgical Pathology·Gitika AggarwalSuash Sharma

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